ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
MicroRNA-10b and minichromosome maintenance complex component 5 gene as prognostic biomarkers in breast cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Organotypic 3D Cell-Architecture Impacts the Expression Pattern of miRNAs-mRNAs Network in Breast Cancer SKBR3 Cells.Non-coding RNA · 2023Article
- Camouflaged Hybrid Cancer Cell-Platelet Fusion Membrane Nanovesicles Deliver Therapeutic MicroRNAs to Presensitize Triple-Negative Breast Cancer to Doxorubicin.Advanced functional materials · 2021Article
- Increased expression ofJournal of gastrointestinal oncology · 2021Article
- Potential Prospective Biomarkers for Non-small Cell Lung Cancer: Mini-Chromosome Maintenance Proteins.Frontiers in genetics · 2021Article
- Prognostic role of minichromosome maintenance family in multiple myeloma.Cancer gene therapy · 2020Article
- Expression Profile and Prognostic Values of Mini-Chromosome Maintenance Families (MCMs) in Breast Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer.Oncology research · 2020Article
- Construction and validation of a 6-gene nomogram discriminating lung metastasis risk of breast cancer patients.PloS one · 2020Article
- The Emerging Role of MicroRNAs in Breast Cancer.Journal of oncology · 2020Review
- Prognostic role of microRNAs in breast cancer: A systematic review.Oncotarget · 2019Article
- Minichromosome Maintenance Complex (MCM) Genes Profiling and MCM2 Protein Expression in Cervical Cancer Development.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- MCM5 promotes tumour proliferation and correlates with the progression and prognosis of renal cell carcinoma.International urology and nephrology · 2019Article
- Article
- MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression.BMC cancer · 2018Review
- miR-539 acts as a tumor suppressor by targeting epidermal growth factor receptor in breast cancer.Scientific reports · 2018Article
- The fundamental role of miR-10b in metastatic cancer.American journal of cancer research · 2018Review
- Identification of Significant Gene Signatures and Prognostic Biomarkers for Patients With Cervical Cancer by Integrated Bioinformatic Methods.Technology in cancer research & treatment · 2018Article
- The prognostic significance of Cdc6 and Cdt1 in breast cancer.Scientific reports · 2017Article
- Clinical Value of miR-101-3p and Biological Analysis of its Prospective Targets in Breast Cancer: A Study Based on The Cancer Genome Atlas (TCGA) and Bioinformatics.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Applications of Extracellular RNAs in Oncology.Molecular diagnosis & therapy · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to identify micro-ribonucleic acid (microRNA) and its target, in addition to their relationship to the outcome in breast cancer (BC). To achieve this aim, we investigated microRNA-10b (miR-10b) and minichromosome maintenance complex component 5 (MCM5 mRNA) expression in 230 breast tissue samples by real-time PCR and semiquantitative conventional RT-PCR, respectively. Relapse-free survival (RFS) associated with miRNA-10b and MCM5 mRNA were tested by Kaplan-Meier survival analysis. The impact of miRNA-10b andMCM5 mRNA expression on the survival was evaluated by Cox proportional hazard regression model. The expression of miRNA-10b and MCM5 mRNA was positive in 86.4 and 79.7 % breast cancer patients, respectively. The overall concordance rate between miRNA-10b and MCM5 RNA was 90.4 %. The median follow-up period was 50 months. The survival analysis showed that high levels of both miR-10b and MCM5 were associated with short relapse free survival of BC. We identified MCM5 mRNA expression changes consistent with the miRNA-10b target regulation. Thus, we could consider miRNA-10b and MCM5 mRNA as prognostic markers and potential therapeutic targets in breast cancer to be applied to other patient data sets.
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