ArticleCerebral cortex (New York, N.Y. : 1991)2016
Prefrontal Cortical Inactivations Decrease Willingness to Expend Cognitive Effort on a Rodent Cost/Benefit Decision-Making Task.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effects of chemotherapy on cognitive and physical effort-based decision-making tasks in rats.Psychopharmacology · 2026Article
- Revealing abrupt transitions from goal-directed to habitual behavior.Nature communications · 2026Article
- Article
- Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism.Hormones and behavior · 2024Article
- Prelimbic Cortex Activity during a Distress Tolerance Task Predicts Cocaine-Seeking Behavior in Male, But Not Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Bedside to bench: the outlook for psychedelic research.Frontiers in pharmacology · 2023Review
- Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury.Psychopharmacology · 2022Article
- Sleep Restriction Reduces Cognitive but Not Physical Motivation.Nature and science of sleep · 2022Article
- Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia.NPJ schizophrenia · 2021Article
- Mental labour.Nature human behaviour · 2018Review
- Persistent effect of withdrawal from intravenous methamphetamine self-administration on brain activation and behavioral economic indices involving an effort cost.Neuropharmacology · 2018Article
- Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex.eLife · 2018Article
- ΔJournal of psychiatry & neuroscience : JPN · 2017Article
- Developmental Exposure to Cocaine Dynamically Dysregulates Cortical Arc/Arg3.1 Modulation in Response to a Challenge.Neurotoxicity research · 2017Article
- Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- The role of cognitive effort in subjective reward devaluation and risky decision-making.Scientific reports · 2015Article
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Authors and funding
3 authors.
Funding
Abstract
Personal success often necessitates expending greater effort for greater reward but, equally important, also requires judicious use of our limited cognitive resources (e.g., attention). Previous animal models have shown that the prelimbic (PL) and infralimbic (IL) regions of the prefrontal cortex (PFC) are not involved in (physical) effort-based choice, whereas human studies have demonstrated PFC contributions to (mental) effort. Here, we utilize the rat Cognitive Effort Task (rCET) to probe PFC's role in effort-based decision making. In the rCET, animals can choose either an easy trial, where the attentional demand is low but the reward (sugar) is small or a difficult trial on which both the attentional demand and reward are greater. Temporary inactivation of PL and IL decreased all animals' willingness to expend mental effort and increased animals' distractibility; PL inactivations more substantially affected performance (i.e., attention), whereas IL inactivations increased motor impulsivity. These data imply that the PFC contributes to attentional resources, and when these resources are diminished, animals shift their choice (via other brain regions) accordingly. Thus, one novel therapeutic approach to deficits in effort expenditure may be to focus on the resources that such decision making requires, rather than the decision-making process per se.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.