Evidence map›Paper›PMID 25596503›Full record

Observational studyNeurology2015

Inflammation, negative nitrogen balance, and outcome after aneurysmal subarachnoid hemorrhage.

Neeraj Badjatia, Aimee Monahan, Amanda Carpenter, Jacqueline Zimmerman, J Michael Schmidt, Jan Claassen, E Sander Connolly, Stephan A Mayer, Wahida Karmally, David Seres

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Body composition and rupture risk of intracranial aneurysms.European journal of medical research · 2024
    Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Neeraj BadjatiaFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY. nbadjatia@som.umaryland.edu.
Aimee MonahanFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
Amanda CarpenterFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
Jacqueline ZimmermanFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
J Michael SchmidtFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
Jan ClaassenFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
E Sander ConnollyFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
Stephan A MayerFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
Wahida KarmallyFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
David SeresFrom the Section of Neurocritical Care and Emergency Neurology, Program in Trauma, Department of Neurology (N.B.), University of Maryland School of Medicine, Baltimore; and the Neurological Institute of New York (A.M., A.C., J.Z., J.M.S., J.C., E.S.C., S.A.M.), Institute of Human Nutrition (W.K.), and Division of Preventive Medicine and Nutrition, Department of Internal Medicine (D.S.), Columbia University College of Physicians and Surgeons, New York, NY.
University of Maryland, Baltimore · US

Funding

CTSA: K12 COMPONENTKL2RR024157 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$8.9M
Clinical and Translational Science AwardKL2TR000081 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$3.3M
NCATS NIH HHS KL2 TR000081NCRR NIH HHS KL2 RR024157
6 · The paper itself

Abstract

objectiveTo analyze the impact of inflammation and negative nitrogen balance (NBAL) on nutritional status and outcomes after subarachnoid hemorrhage (SAH).

methodsThis was a prospective observational study of SAH patients admitted between May 2008 and June 2012. Measurements of C-reactive protein (CRP), transthyretin (TTR), resting energy expenditure (REE), and NBAL (g/day) were performed over 4 preset time periods during the first 14 postbleed days (PBD) in addition to daily caloric intake. Factors associated with REE and NBAL were analyzed with multivariable linear regression. Hospital-acquired infections (HAI) were tracked daily for time-to-event analyses. Poor outcome at 3 months was defined as a modified Rankin Scale score ≥ 4 and assessed by multivariable logistic regression.

resultsThere were 229 patients with an average age of 55 ± 15 years. Higher REE was associated with younger age (p = 0.02), male sex (p < 0.001), higher Hunt Hess grade (p = 0.001), and higher modified Fisher score (p = 0.01). Negative NBAL was associated with lower caloric intake (p < 0.001), higher body mass index (p < 0.001), aneurysm clipping (p = 0.03), and higher CRP:TTR ratio (p = 0.03). HAIs developed in 53 (23%) patients on mean PBD 8 ± 3. Older age (p = 0.002), higher Hunt Hess (p < 0.001), lower caloric intake (p = 0.001), and negative NBAL (p = 0.04) predicted time to first HAI. Poor outcome at 3 months was associated with higher Hunt Hess grade (p < 0.001), older age (p < 0.001), negative NBAL (p = 0.01), HAI (p = 0.03), higher CRP:TTR ratio (p = 0.04), higher body mass index (p = 0.03), and delayed cerebral ischemia (p = 0.04).

conclusionsNegative NBAL after SAH is influenced by inflammation and associated with an increased risk of HAI and poor outcome. Underfeeding and systemic inflammation are potential modifiable risk factors for negative NBAL and poor outcome after SAH.

Indexed as

C-Reactive ProteinCross InfectionEnergy IntakeEnergy MetabolismFemaleHumansInflammationIntracranial AneurysmMaleMiddle AgedNitrogenPrealbuminPrognosisProspective StudiesRestSubarachnoid HemorrhageC-Reactive ProteinNitrogenPrealbumin

Identifiers

PMID25596503
PMCPMC4336106
OpenAlexW2161789832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.