Evidence map›Paper›PMID 25596364›Full record

ReviewCurrent opinion in neurobiology2015

Resolution revolution: epilepsy dynamics at the microscale.

Gergely G Szabo, Calvin J Schneider, Ivan Soltesz

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Seizure Prediction: Science Fiction or Soon to Become Reality?Current neurology and neuroscience reports · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gergely G SzaboDepartment of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.
Calvin J SchneiderDepartment of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.
Ivan SolteszDepartment of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA. Electronic address: isoltesz@uci.edu.

Funding

GABAergic regulation of entorhino-hippocampal excitability in epilepsy.R01NS074432 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2011 to 2015
$1.6M
NINDS NIH HHS NS74432NINDS NIH HHS R01 NS074432
6 · The paper itself

Abstract

Our understanding of the neuronal mechanisms behind epilepsy dynamics has recently advanced due to the application of novel technologies, monitoring hundreds of neurons with single cell resolution. These developments have provided new theories on the relationship between physiological and pathological states, as well as common motifs for the propagation of paroxysmal activity. Although traditional electroencephalogram (EEG) recordings continue to describe normal network oscillations and abnormal epileptic events within and outside of the seizure focus, analysis of epilepsy dynamics at the microscale has found variability in the composition of macroscopically repetitive epileptiform events. These novel results point to heterogeneity in the underlying dynamics of the disorder, highlighting both the need and potential for more specific and targeted therapies.

Indexed as

AnimalsBrainElectroencephalographyEpilepsyHumansNerve NetNeuronsNonlinear Dynamics

Identifiers

PMID25596364
PMCPMC4375062

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.