ArticleBMJ open2015
The association between daily physical activity and plasma B-type natriuretic peptide in patients with glucose intolerance: a cross-sectional study.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Association between Visceral or Subcutaneous Fat Accumulation and B-Type Natriuretic Peptide among Japanese Subjects: A Cross-Sectional Study.Journal of clinical medicine · 2021Article
- The relationships between three-axis accelerometer measures of physical activity and motor symptoms in patients with Parkinson's disease: a single-center pilot study.BMC neurology · 2020Article
- Natriuretic Peptides: The Case of Prostate Cancer.Molecules (Basel, Switzerland) · 2017Review
- Daily physical activity and type 2 diabetes: A review.World journal of diabetes · 2016Review
- The Effects of Exercise on Natriuretic Peptides in Individuals without Heart Failure.Sports (Basel, Switzerland) · 2016Review
- Serum Zn/Cu Ratio Is Associated with Renal Function, Glycemic Control, and Metabolic Parameters in Japanese Patients with and without Type 2 Diabetes: A Cross-sectional Study.Frontiers in endocrinology · 2016Article
- Observational
- Ichnotaxonomic review of large ornithopod dinosaur tracks: temporal and geographic implications.PloS one · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn spite of accumulating evidences suggesting an inverse association between insulin resistance and plasma B-type natriuretic peptide (BNP) levels, the effect of daily physical activity on plasma BNP in individuals with glucose intolerance remains unknown. We investigated the association of physical activity level (PAL) with plasma BNP in patients with impaired fasting glucose, impaired glucose tolerance and type 2 diabetes.
designCross-sectional study.
settingOutpatients visiting the National Center for Global Health and Medicine Kohnodai Hospital.
participantsA total of 60 patients with glucose intolerance who did not take any hypoglycaemic agents, cholesterol-lowering agents and antihypertensive agents were recruited. Patients who were diagnosed as having heart failure and renal impairment, engaged in sports-like exercise and resistance training were excluded. PRIMARY OUTCOME MEASURES: PAL was objectively measured by a triaxial accelerometer. The association between PAL and plasma BNP levels was assessed by multiple regression analysis.
resultsPAL was positively correlated with plasma BNP levels (r=0.296, p=0.021). PAL was still significantly correlated with plasma BNP levels after adjustment for age (β=0.290, p=0.014), and adjustment for age and body mass index (β=0.282, p=0.018). Plasma BNP levels were inversely correlated with serum insulin levels (r=-0.350, p=0.006) and homeostasis model assessment-estimated insulin resistance (HOMA-IR; r=-0.363, p=0.004). Serum insulin levels (mean±SD, 8.1±6.4 μU/mL) and HOMA-IR (2.4±1.9) in the high-BNP group were significantly lower than those (11.2±7.4 μU/mL and 3.7±3.0, respectively) in the low-BNP group.
conclusionsOur findings propose the possibility that plasma BNP may be increased by daily physical activity and BNP is associated with insulin resistance.
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