ArticlePlant physiology2015
ECERIFERUM2-LIKE proteins have unique biochemical and physiological functions in very-long-chain fatty acid elongation.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 137 citations in OpenAlex.
- Molecular understanding of plant pollination, fertilization, seed development and protoplast regeneration.Science China. Life sciences · 2026Review
- Genome-wide analysis of KCS gene family in sunflower reveals the involvement of HaKCS1-1 in wax biosynthesis and drought resistance.BMC plant biology · 2026Article
- Loss-of-Function Mutation in CER2-LIKE1 Reduced Accumulation of Cuticular Wax and Susceptibility to Thrips in Welsh Onion.Plant biotechnology journal · 2026Article
- Mediator subunit MED25 represses ABI5-dependent activation of erucic acid biosynthetic geneFrontiers in plant science · 2026Article
- Structural basis of VLCFA chain-length determination by the KCS6-CER2 complex in plants.Science advances · 2025Article
- Identification of a Leaf Cuticular Wax Biosynthesis GenePlants (Basel, Switzerland) · 2025Article
- Blue-light-enhanced interaction between ZmCRY1s and GL2 modulates epidermal wax composition in Zea mays.Nature communications · 2025Article
- Structural assembly of maize CRY-GL2 photosignaling complex provides insights into its regulatory role in cuticular wax biosynthesis.Science advances · 2025Article
- Molecular basis of very-long-chain fatty acid elongation by the CER6-GL2 enzyme complex in plant wax biosynthesis.Science advances · 2025Article
- Article
- Insights into the Molecular Basis of Pollen Coat Development and Its Role in Male Sterility.International journal of molecular sciences · 2025Review
- Genome-wide characterization of the Eceriferum (CER) gene family in barley (Hordeum vulgare L.).Scientific reports · 2025Article
- A premature termination codon mutation in the onionHorticulture research · 2025Article
- Advances in plant male sterility for hybrid seed production: an overview of conditional nuclear male sterile lines and biotechnology-based male sterile systems.Frontiers in plant science · 2025Review
- A β-ketoacyl-CoA synthase encoded by DDP1 controls rice anther dehiscence and pollen fertility by maintaining lipid homeostasis in the tapetum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Gene expression profiles and metabolic pathways responsible for male sterility in cybrid pummelo.Plant cell reports · 2024Article
- Dynamic relationships among pathways producing hydrocarbons and fatty acids of maize silk cuticular waxes.Plant physiology · 2024Article
- Wheat MIXTA-like Transcriptional Activators Positively Regulate Cuticular Wax Accumulation.International journal of molecular sciences · 2024Article
- Decoding drought resilience: a comprehensive exploration of the cotton Eceriferum (CER) gene family and its role in stress adaptation.BMC plant biology · 2024Article
- Broad Chain-Length Specificity of the Alkane-Forming Enzymes NoCER1A and NoCER3A/B in Nymphaea odorata.Plant & cell physiology · 2024Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extension of very-long-chain fatty acids (VLCFAs) for the synthesis of specialized apoplastic lipids requires unique biochemical machinery. Condensing enzymes catalyze the first reaction in fatty acid elongation and determine the chain length of fatty acids accepted and produced by the fatty acid elongation complex. Although necessary for the elongation of all VLCFAs, known condensing enzymes cannot efficiently synthesize VLCFAs longer than 28 carbons, despite the prevalence of C28 to C34 acyl lipids in cuticular wax and the pollen coat. The eceriferum2 (cer2) mutant of Arabidopsis (Arabidopsis thaliana) was previously shown to have a specific deficiency in cuticular waxes longer than 28 carbons, and heterologous expression of CER2 in yeast (Saccharomyces cerevisiae) demonstrated that it can modify the acyl chain length produced by a condensing enzyme from 28 to 30 carbon atoms. Here, we report the physiological functions and biochemical specificities of the CER2 homologs CER2-LIKE1 and CER2-LIKE2 by mutant analysis and heterologous expression in yeast. We demonstrate that all three CER2-LIKEs function with the same small subset of condensing enzymes, and that they have different effects on the substrate specificity of the same condensing enzyme. Finally, we show that the changes in acyl chain length caused by each CER2-LIKE protein are of substantial importance for cuticle formation and pollen coat function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.