ArticleLife sciences2015
Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling.
Article in Life sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Association Between Mitral Annular Calcification and Ventricular Tachycardia in Patients with Reduced and Mildly Reduced Ejection Fraction.Journal of clinical medicine · 2026Article
- Acute GLP-1 Agonism Induces Arrhythmogenic Electrical Activity in Aged Mice Heart Through Impaired Cellular Na+ and Ca2+ Handlings: The Role of CK2 Hyperphosphorylation.Anatolian journal of cardiology · 2025Article
- Cardiomyocyte Reduction of Hybrid/Complex N-Glycosylation in the Adult Causes Heart Failure With Reduced Ejection Fraction in the Absence of Cellular Remodeling.Journal of the American Heart Association · 2024Article
- Gab1 Overexpression Attenuates Susceptibility to Ventricular Arrhythmias in Pressure Overloaded Heart Failure Mouse Hearts.Cardiovascular drugs and therapy · 2024Article
- Pro-Arrhythmic Effects of Discontinuous Conduction at the Purkinje Fiber-Ventricle Junction Arising From Heart Failure-Induced Ionic Remodeling - Insights From Computational Modelling.Frontiers in physiology · 2022Article
- Arrhythmogenic Remodeling in the Failing Heart.Cells · 2021Review
- A single injection of periostin decreases cardiac voltage-gated NaThe Journal of veterinary medical science · 2021Article
- Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease.Journal of inflammation research · 2021Review
- Cardiac protection of germinated brown rice extract in rabbit model of chronic myocardial infarction.Translational animal science · 2020Article
- Pro-Arrhythmic Ventricular Remodeling Is Associated With Increased Respiratory and Low-Frequency Oscillations of Monophasic Action Potential Duration in the Chronic Atrioventricular Block Dog Model.Frontiers in physiology · 2019Article
- IFrontiers in pharmacology · 2019Article
- Mechanisms Underlying Interactions Between Low-Frequency Oscillations and Beat-to-Beat Variability of Celullar Ventricular Repolarization in Response to Sympathetic Stimulation: Implications for Arrhythmogenesis.Frontiers in physiology · 2019Article
- Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases.Frontiers in immunology · 2019Review
- Prolonged QTc indicates the clinical severity and poor prognosis in patients with isolated left ventricular non-compaction.The international journal of cardiovascular imaging · 2017Article
- Correlation of Ventricular Arrhythmogenesis with Neuronal Remodeling of Cardiac Postganglionic Parasympathetic Neurons in the Late Stage of Heart Failure after Myocardial Infarction.Frontiers in neuroscience · 2017Article
- Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents.Circulation research · 2016Article
- Variability of Myocardial Repolarization in Pediatric Patients with a Ventricular Septal Defect.Pediatric cardiology · 2016Article
- Dysfunction of the β2-spectrin-based pathway in human heart failure.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
aimsVentricular arrhythmias are a common cause of death in patients with heart failure (HF). Structural and electrical abnormalities in the heart provide a substrate for such arrhythmias. Canine tachypacing-induced HF models of 4-6 weeks duration are often used to study pathophysiology and therapies for HF. We hypothesized that a chronic canine model of HF would result in greater electrical and structural remodeling than a short term model, leading to a more arrhythmogenic substrate. MAIN
methodsHF was induced by ventricular tachypacing for one (short-term) or four (chronic) months to study remodeling. KEY
findingsLeft ventricular contractility was progressively reduced, while ventricular hypertrophy and interstitial fibrosis were evident at 4 month but not 1 month of HF. Left ventricular myocyte action potentials were prolonged after 4 (p<0.05) but not 1 month of HF. Repolarization instability and early afterdepolarizations were evident only after 4 months of HF (p<0.05), coinciding with a prolonged QTc interval (p<0.05). The transient outward potassium current was reduced in both HF groups (p<0.05). The outward component of the inward rectifier potassium current was reduced only in the 4 month HF group (p<0.05). The delayed rectifier potassium currents were reduced in 4 (p<0.05) but not 1 month of HF. Reactive oxygen species were increased at both 1 and 4 months of HF (p<0.05). SIGNIFICANCE: Reduced Ito, outward IK1, IKs, and IKr in HF contribute to EAD formation. Chronic, but not short term canine HF, results in the altered electrophysiology and repolarization instability characteristic of end-stage human HF.
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