ArticleNeuroscience2015
Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model.
Article in Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Sex differences in resilience at puberty depend upon divergent effects of a stress steroid at α4βδ GABABrain research · 2025Article
- Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation.Endocrinology · 2023Article
- Central amygdala corticotropin-releasing factor neurons promote hyponeophagia but do not control alcohol drinking in mice.Molecular psychiatry · 2022Article
- Neuroendocrine control of appetite and metabolism.Experimental & molecular medicine · 2021Review
- Single-cell morphological characterization of CRH neurons throughout the whole mouse brain.BMC biology · 2021Article
- Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Involvement of the ventral, but not dorsal, hippocampus in anxiety-like behaviors in mice exposed to the elevated plus maze: participation of CRF1 receptor and PKA pathway.Pharmacological reports : PR · 2021Article
- Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y.Annals of the New York Academy of Sciences · 2019Review
- Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice.Frontiers in nutrition · 2019Article
- Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress.Journal of nutrition and metabolism · 2018Article
- Contribution of amygdala CRF neurons to chronic pain.Experimental neurology · 2017Article
- A Quantitative Analysis of the Distribution of CRH Neurons in Whole Mouse Brain.Frontiers in neuroanatomy · 2017Article
- Activation of corticotropin releasing factor-containing neurons in the rat central amygdala and bed nucleus of the stria terminalis following exposure to two different anxiogenic stressors.Behavioural brain research · 2016Article
- Posterodorsal Medial Amygdala Mediates Tail-Pinch Induced Food Intake in Female Rats.Journal of neuroendocrinology · 2016Article
- Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus.Psychoneuroendocrinology · 2016Article
- Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome.Journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The corticotropin-releasing factor (CRF)-producing neurons of the amygdala have been implicated in behavioral and physiological responses associated with fear, anxiety, stress, food intake and reward. To overcome the difficulties in identifying CRF neurons within the amygdala, a novel transgenic mouse line, in which the humanized recombinant Renilla reniformis green fluorescent protein (hrGFP) is under the control of the CRF promoter (CRF-hrGFP mice), was developed. First, the CRF-hrGFP mouse model was validated and the localization of CRF neurons within the amygdala was systematically mapped. Amygdalar hrGFP-expressing neurons were located primarily in the interstitial nucleus of the posterior limb of the anterior commissure, but also present in the central amygdala. Secondly, the marker of neuronal activation c-Fos was used to explore the response of amygdalar CRF neurons in CRF-hrGFP mice under different experimental paradigms. C-Fos induction was observed in CRF neurons of CRF-hrGFP mice exposed to an acute social defeat stress event, a fasting/refeeding paradigm or lipopolysaccharide (LPS) administration. In contrast, no c-Fos induction was detected in CRF neurons of CRF-hrGFP mice exposed to restraint stress, forced swimming test, 48-h fasting, acute high-fat diet (HFD) consumption, intermittent HFD consumption, ad libitum HFD consumption, HFD withdrawal, conditioned HFD aversion, ghrelin administration or melanocortin 4 receptor agonist administration. Thus, this study fully characterizes the distribution of amygdala CRF neurons in mice and suggests that they are involved in some, but not all, stress or food intake-related behaviors recruiting the amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.