ArticleThe Plant cell2015
A transient receptor potential ion channel in Chlamydomonas shares key features with sensory transduction-associated TRP channels in mammals.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Integrative genomic, phylogenetic, and transcriptomic analyses reveal temperature-responsive transient receptor potential (TRP) genes in Pacific abalone Haliotis discus hannai.BMC ecology and evolution · 2026Article
- Shear-induced ciliary autotomy mediated by a TRP channel and a voltage-dependent calcium channel.iScience · 2025Article
- Channels of Evolution: Unveiling Evolutionary Patterns in Diatom CaPlants (Basel, Switzerland) · 2024Article
- Mechanoresponses mediated by the TRP11 channel in cilia ofiScience · 2023Article
- Post-injury pain and behaviour: a control theory perspective.Nature reviews. Neuroscience · 2023Review
- Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.Biological research · 2023Article
- Membrane-anchored calpains - hidden regulators of growth and development beyond plants?Frontiers in plant science · 2023Article
- Mechanosensitive channels in lung disease.Frontiers in physiology · 2023Review
- The Genome of the Marine AlgaInternational journal of molecular sciences · 2022Article
- Chlamydomonas reinhardtii cellular compartments and their contribution to intracellular calcium signalling.Journal of experimental botany · 2021Review
- Transient receptor potential channels in sensory mechanisms of the lower urinary tract.Nature reviews. Urology · 2021Review
- Ion Channels in Glioma Malignancy.Reviews of physiology, biochemistry and pharmacology · 2021Review
- Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature.Proceedings. Biological sciences · 2020Article
- Responses to transient receptor potential (TRP) channel agonists inBiology open · 2020Article
- Evolutionary Aspects of TRPMLs and TPCs.International journal of molecular sciences · 2020Review
- Plant Membrane Transport Research in the Post-genomic Era.Plant communications · 2020Review
- TransgenicFrontiers in pharmacology · 2020Article
- Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii.Nature communications · 2019Article
- Transient Receptor Potential Channels and Calcium Signaling.Cold Spring Harbor perspectives in biology · 2019Review
- CaScientific reports · 2018Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory modalities are essential for navigating through an ever-changing environment. From insects to mammals, transient receptor potential (TRP) channels are known mediators for cellular sensing. Chlamydomonas reinhardtii is a motile single-celled freshwater green alga that is guided by photosensory, mechanosensory, and chemosensory cues. In this type of alga, sensory input is first detected by membrane receptors located in the cell body and then transduced to the beating cilia by membrane depolarization. Although TRP channels seem to be absent in plants, C. reinhardtii possesses genomic sequences encoding TRP proteins. Here, we describe the cloning and characterization of a C. reinhardtii version of a TRP channel sharing key features present in mammalian TRP channels associated with sensory transduction. In silico sequence-structure analysis unveiled the modular design of TRP channels, and electrophysiological experiments conducted on Human Embryonic Kidney-293T cells expressing the Cr-TRP1 clone showed that many of the core functional features of metazoan TRP channels are present in Cr-TRP1, suggesting that basic TRP channel gating characteristics evolved early in the history of eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.