Evidence map›Paper›PMID 25595805›Full record

ReviewProgress in molecular biology and translational science2015

Picornavirus--host interactions to construct viral secretory membranes.

Alexander L Greninger

Open access · greenAbstract readReview
In one paragraph

Review in Progress in molecular biology and translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
31.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alexander L GreningerSchool of Medicine, University of California, San Francisco, California, USA. Electronic address: gerbix@gmail.com.
University of California, San Francisco · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

Picornaviruses are positive-stranded RNA viruses of significant disease burden and ubiquitous global reach. Microscopic examination of picornavirus-infected cells has long revealed a drastic reordering of intracellular membranes. Through a confluence of candidate-based approaches and genomic and proteomic screens, the past decade has seen great leaps in understanding how picornaviruses usurp intracellular membranes for their own replication. The growing cast of assembled characters allows for a rich plot in the upcoming years. With their widespread genomic divergence, the number of potential mechanisms for RNA virus vesicogenesis for driving membrane formation and lipid synthesis required for viral replication is broad, but the overall story arch remains surprisingly recognizable. This chapter reviews the major discoveries associating picornavirus pathogenic interactions with the secretory system and highlights important questions and opportunities for future study.

Indexed as

Host-Pathogen InteractionsSecretory PathwayAmino Acid SequenceAnimalsCholesterolHumansIntracellular MembranesMolecular Sequence DataPicornaviridaeViral ProteinsCholesterolViral Proteins2BC3A3A proteinACBD3Aichi virusCholesterolCoxsackievirusEnterovirusFlavivirusGBF1KlassevirusKobuvirusMembranePhosphatidylinositolPI4KBPI4PPicornavirusPolioPoliovirusRhinovirusRNA virus

Identifiers

PMID25595805
PMCPMC12716941
OpenAlexW154694743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.