Evidence map›Paper›PMID 25595665›Full record

Trial reportPM & R : the journal of injury, function, and rehabilitation2015

Strategy Training During Inpatient Rehabilitation May Prevent Apathy Symptoms After Acute Stroke.

Elizabeth R Skidmore, Ellen M Whyte, Meryl A Butters, Lauren Terhorst, Charles F Reynolds

Open access · bronzeAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in PM & R : the journal of injury, function, and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Motivation as a Measurable Outcome in Stroke Rehabilitation: A Systematic Review of the Literature.International journal of environmental research and public health · 2023
    Pooled it
  3. Occupational therapy for cognitive impairment in stroke patients.The Cochrane database of systematic reviews · 2022
    Pooled it
  4. Pooled it
  5. Trial
  6. Lesion location may attenuate response to strategy training in acute stroke.PM & R : the journal of injury, function, and rehabilitation · 2022
    Trial
  7. Article
  8. Review
  9. Article
  10. Review
  11. Cerebral small vessel disease: Recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2023
    Review
  12. Article
  13. Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.International journal of stroke : official journal of the International Stroke Society · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Developing a Non-Pharmacological Intervention for Individuals With Mild Cognitive Impairment.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Elizabeth R SkidmoreDepartment of Occupational Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences, University of Pittsburgh, 5012 Forbes Tower, Pittsburgh, PA 15260; and Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA(∗). Electronic address: skidmore@pitt.edu.
Ellen M WhyteDepartment of Physical Medicine & Rehabilitation and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; and Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA(†).
Meryl A ButtersDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; and Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA(‡).
Lauren TerhorstDepartment of Occupational Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences, Pittsburgh, PA(§).
Charles F ReynoldsDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; and Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA(‖).
Western State Hospital · USAmerican Foundation for Suicide Prevention · USUnited States Congress · USUniversity of Pittsburgh · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
MULTICENTER CAREER DEVELOPMENT PROGRAM FOR PHYSICAL AND OCCUPATIONAL THERAPYK12HD055931 · NICHD · WASHINGTON UNIVERSITY · PI HAYES, MARCIE HARRIS · 2007 to 2021
$12.7M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F. · 2011 to 2015
$8.3M
Optimizing Environmental Enrichment to Model Preclinical NeurorehabilitationR01NS084967 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2014 to 2025
$3.7M
Closing Gap in Stroke Rehabilitation: Early Intervention for Cognitive DisabilityR01HD074693 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SKIDMORE, ELIZABETH RENEE · 2013 to 2018
$2.6M
Donepezil to promote functional recovery post-strokeR01HD055525 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHYTE, ELLEN M · 2009 to 2013
$2.1M
Developing Cognitive Training and Rehabilitation Paradigms for Experimental TBIR21HD071728 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WAGNER, AMY K · 2012 to 2013
$407k
Guided Versus Directed Training in Acute Stroke RehabilitationR03HD073770 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SKIDMORE, ELIZABETH RENEE · 2012 to 2013
$148k
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NIA NIH HHS P30 AG024827NICHD NIH HHS 1R01HD055525NICHD NIH HHS K12 HD055931NICHD NIH HHS R01HD055525NICHD NIH HHS R01 HD074693NICHD NIH HHS R03HD073770NICHD NIH HHS R21HD071728NIMH NIH HHS P30 MH090333NINDS NIH HHS R01NS084967PHS HHS H133A120087
6 · The paper itself

Abstract

backgroundApathy, or lack of motivation for goal-directed activities, contributes to reduced engagement in and benefit from rehabilitation, impeding recovery from stroke.

objectiveTo examine the effects of strategy training, a behavioral intervention used to augment usual inpatient rehabilitation, on apathy symptoms over the first 6 months after stroke.

designSecondary analysis of randomized controlled trial.

settingAcute inpatient rehabilitation.

participantsParticipants with acute stroke who exhibited cognitive impairments (Quick Executive Interview Scores ≥3) and were admitted for inpatient rehabilitation were randomized to receive strategy training (n = 15, 1 session per day, 5 days per week, in addition to usual inpatient rehabilitation) or reflective listening (n = 15, same dose).

methodsStrategy training sessions focused on participant-selected goals and participant-derived strategies to address these goals, using a global strategy training method (Goal-Plan-Do-Check). Reflective listening sessions focused on participant reflections on their rehabilitation goals and experiences, facilitated by open-ended questions and active listening skills (attending, following, and responding).

main outcome measuresTrained raters blinded to group assignment administered the Apathy Evaluation Scale at study admission, 3 months, and 6 months. Data were analyzed with repeated-measures fixed-effects models.

resultsParticipants in both groups had similar subsyndromal levels of apathy symptoms at study admission (strategy training, mean = 25.79, standard deviation = 7.62; reflective listening, mean = 25.18, standard deviation = 4.40). A significant group × time interaction (F2,28 = 3.61, P = .040) indicated that changes in apathy symptom levels differed between groups over time. The magnitude of group differences in change scores was large (d = -0.99, t28 = -2.64, P = .013) at month 3 and moderate to large (d = -0.70, t28 = -1.86, P = .073) at month 6.

conclusionStrategy training shows promise as an adjunct to usual rehabilitation for maintaining low levels of poststroke apathy.

Indexed as

Activities of Daily LivingApathyInpatientsPhysical Therapy ModalitiesStroke RehabilitationAgedCognition DisordersFemaleHumansMaleMiddle AgedPilot ProjectsSingle-Blind MethodStroke

Identifiers

PMID25595665
PMCPMC4466065
OpenAlexW2075652726

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.