Evidence map›Paper›PMID 25595660›Full record

ReviewClinical psychology review2015

It's complicated: The relation between cognitive change procedures, cognitive change, and symptom change in cognitive therapy for depression.

Lorenzo Lorenzo-Luaces, Ramaris E German, Robert J DeRubeis

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Clinical psychology review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03796143 (A Randomized Controlled Trial), which is not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 3 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03796143 nacompletednot on this mapstarted 2019, after this paper: background citation

A Randomized Controlled Trial (RCT) Comparing Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT) Self-help Books for Depression

TypeinterventionalSponsorUtah State UniversityRan2019 to 2020Enrolled140ConditionsMental HealthArmsThe Mindfulness and Acceptance Workbook for Depression, The Cognitive Behavioral Workbook for Depression
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 183 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Mechanisms and moderators in mindfulness- and acceptance-based treatments for binge eating spectrum disorders: A systematic review.European eating disorders review : the journal of the Eating Disorders Association · 2019
    Pooled it
  4. Trial
  5. Feasibility Study of a Novel App-Based Anxiety Intervention for Autistic People.Autism research : official journal of the International Society for Autism Research · 2026
    Trial
  6. Trial
  7. Exploring mechanisms of change in the metacognitive training for depression.European archives of psychiatry and clinical neuroscience · 2024
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Article
  17. Targeting mechanisms of change as a path to precision psychotherapy for community settings.Psychotherapy research : journal of the Society for Psychotherapy Research · 2026
    Article
  18. Article
  19. How Are People Undergoing Dialysis Expected to Benefit From Cognitive Behavioural Therapy? A Realist Analysis.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lorenzo Lorenzo-LuacesDepartment of Psychology, University of Pennsylvania, United States.
Ramaris E GermanDepartment of Psychology, University of Pennsylvania, United States.
Robert J DeRubeisDepartment of Psychology, University of Pennsylvania, United States. Electronic address: derubeis@psych.upenn.edu.
University of Pennsylvania · US

Funding

PREVENTION OF RECURRENCE IN DEPRESSION WITH DRUGS AND CTR01MH060998 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DERUBEIS, ROBERT J · 2002 to 2011
$6.5M
Treatment of Bipolar Type II Major DepressionR01MH060353 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DERUBEIS, ROBERT J · 2001 to 2011
$3.9M
1/2-Prevention of Relapse & Recurrence of Bipolar DepressionR01MH080097 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DERUBEIS, ROBERT J · 2009 to 2013
$2.0M
COGNITIVE THERAPY AND PHARMACOTHERAPY FOR DEPRESSIONR10MH055877 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DERUBEIS, ROBERT J · 1996 to 2000
$314k
NIMH NIH HHS R01 MH060353NIMH NIH HHS R01 MH060998NIMH NIH HHS R01 MH080097NIMH NIH HHS R10 MH055877
6 · The paper itself

Abstract

Many attempts have been made to discover and characterize the mechanisms of change in psychotherapies for depression, yet no clear, evidence-based account of the relationship between therapeutic procedures, psychological mechanisms, and symptom improvement has emerged. Negatively-biased thinking plays an important role in the phenomenology of depression, and most theorists acknowledge that cognitive changes occur during successful treatments. However, the causal role of cognitive change procedures in promoting cognitive change and alleviating depressive symptoms has been questioned. We describe the methodological and inferential limitations of the relevant empirical investigations and provide recommendations for addressing them. We then develop a framework within which the possible links between cognitive procedures, cognitive change, and symptom change can be considered. We conclude that cognitive procedures are effective in alleviating symptoms of depression and that cognitive change, regardless of how it is achieved, contributes to symptom change, a pattern of findings that lends support to the cognitive theory of depression.

Indexed as

Psychotherapeutic ProcessesTreatment OutcomeCognitive Behavioral TherapyHumansMajor Depressive DisorderCognitive changeCognitive therapyMechanisms of changeMediationPsychotherapy processes

Identifiers

PMID25595660
PMCPMC10080251
OpenAlexW1984747549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.