Evidence map›Paper›PMID 25595621›Full record

ArticleLupus2015

Systemic lupus erythematosus is not a risk factor for poor outcomes after total hip and total knee arthroplasty.

U H Shah, L A Mandl, C Mertelsmann-Voss, Y Y Lee, M M Alexiades, M P Figgie, S M Goodman

Abstract read
In one paragraph

Article in Lupus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  4. Global mapping of institutional and hospital-based (Level II-IV) arthroplasty registries: a scoping review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

U H ShahDepartment of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY, USA.
L A MandlDepartment of Medicine, Division of Rheumatology, Hospital for Special Surgery, New York, NY, USA.
C Mertelsmann-VossDepartment of Medicine, Division of Pediatric Rheumatology, Winthrop University Hospital, Mineola, NY, USA.
Y Y LeeDepartment of Research, Hospital for Special Surgery, New York, NY, USA.
M M AlexiadesDepartment of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.
M P FiggieDepartment of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.
S M GoodmanDepartment of Medicine, Division of Rheumatology, Hospital for Special Surgery, New York, NY, USA GoodmanS@HSS.edu.
Hospital for Special Surgery · USNew York University Langone Orthopedic Hospital · USWinthrop-University Hospital · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
The Centers for Education and Research on Therapeutics *U18HS016075 · AHRQ · WEILL MEDICAL COLL OF CORNELL UNIV · PI MUSHLIN, ALVIN MUSHLIN · 2006 to 2010
$4.0M
AHRQ HHS U18 HS016075NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1-TR000457-06
6 · The paper itself

Abstract

objectivesHistorically, arthroplasty in systemic lupus erythematosus (SLE) patients has been less successful than for patients with osteoarthritis (OA). It is not known if SLE remains an independent risk factor for poor arthroplasty outcomes or if other factors, such as avascular necrosis (AVN), continue to play a role.

methodsA case-control study using data from a single-institution arthroplasty registry compared SLE total hip arthroplasty (THA) and total knee arthroplasty (TKA) with OA controls matched by age, gender and presence of AVN. Baseline, two-year administrative and self-report data, and diagnosis leading to arthroplasty were evaluated.

resultsA total of 54 primary SLE THA and 45 primary SLE TKA were identified from May 2007 through June 2011. AVN was present in 32% of SLE THA and no TKA. SLE THA had worse preoperative WOMAC pain (42.5 vs. 52.7; p = 0.01) and function (38.8 vs. 48.0; p = 0.05) compared with OA. However, at two years there was no difference in WOMAC pain (91.1 vs. 92.1; p = 0.77) or WOMAC function (86.4 vs. 90.8; p = 0.28). SLE TKA were similar to OA in both preoperative pain (42.6 vs. 48.4; p = 0.14) and function (42.1 vs. 46.8; p = 0.30) and two-year pain (85.7 vs. 88.6; p = 0.50) and function (83.7 vs. 85.1; p = 0.23). Compared to OA, SLE THA and TKA patients had more renal failure (14% vs. 1%; p = 0.007) and hypertension (52% vs. 29%; p = 0.009). In a multivariate linear regression, SLE was not predictive of either poor pain or poor function.

conclusionsWhile SLE patients have more comorbidities than OA, and SLE THA have worse preoperative pain and function compared with OA controls, SLE was not an independent risk factor for poor short-term pain or function after either hip or knee arthroplasty.

Indexed as

AdultAgedArthroplasty, Replacement, HipArthroplasty, Replacement, KneeCase-Control StudiesFemaleHumansLupus Erythematosus, SystemicMaleMiddle AgedOsteonecrosisProspective StudiesQuality of LifeRisk FactorsTreatment Outcomecardiovascular diseasemusculoskeletalSystemic lupus erythematosus

Identifiers

PMID25595621
PMCPMC4504835
OpenAlexW1969096332

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.