ArticleClinical chemistry2015
Clinical sensitivity and specificity of meconium fatty acid ethyl ester, ethyl glucuronide, and ethyl sulfate for detecting maternal drinking during pregnancy.
Article in Clinical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 90 citations in OpenAlex.
- Does a Biochemical Approach Facilitate the Diagnosis of Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder in Neonatal Period?International journal of molecular sciences · 2026Review
- Anonymous Diaper-Based Meconium Collection for Ethyl Glucuronide Analysis: A Pilot Feasibility Study.Toxics · 2026Article
- Prenatal Alcohol Exposure Predicts Academic Outcomes from Childhood to Adolescence: A Prospective Longitudinal Study Based on Meconium Ethyl Glucuronide.Behavioral sciences (Basel, Switzerland) · 2026Article
- Article
- Comparing rates of agreement between different diagnostic criteria for fetal alcohol spectrum disorder: A systematic review.Alcohol, clinical & experimental research · 2025Review
- Associations between community-level patterns of prenatal alcohol and tobacco exposure on brain structure in a non-clinical sample of 6-year-old children: a South African pilot study.Acta neuropsychiatrica · 2024Article
- Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice.Neuropharmacology · 2023Article
- Impact of Alcohol Consumption on Multiple Sclerosis Using Model-based Standardization and Misclassification Adjustment Via Probabilistic Bias Analysis.Archives of Iranian medicine · 2023Article
- Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study.BMC medicine · 2023Article
- Associations between prenatal alcohol and tobacco exposure on Doppler flow velocity waveforms in pregnancy: a South African study.BMC pregnancy and childbirth · 2023Article
- Fatty acid metabolism changes in association with neurobehavioral deficits in animal models of fetal alcohol spectrum disorders.Communications biology · 2023Article
- Old and New Biomarkers of Alcohol Abuse: Narrative Review.Journal of clinical medicine · 2023Review
- Impact of Thin Meconium on Delivery and Early Neonatal Outcomes.Children (Basel, Switzerland) · 2023Article
- Screening for Alcohol Use in Pregnancy: a Review of Current Practices and Perspectives.International journal of mental health and addiction · 2023Article
- Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools.Alcohol research : current reviews · 2023Review
- Prenatal alcohol exposure can be determined from baby teeth: Proof of concept.Birth defects research · 2022Article
- Alternative matrices in forensic toxicology: a critical review.Forensic toxicology · 2022Review
- Alcohol's Impact on the Fetus.Nutrients · 2021Review
- Association of Prenatal Alcohol Exposure and Prenatal Maternal Depression with Offspring Low-Grade Inflammation in Early Adolescence.International journal of environmental research and public health · 2021Article
- Role of Neonatal Biomarkers of Exposure to Psychoactive Substances to Identify Maternal Socio-Demographic Determinants.Biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundWe investigated agreement between self-reported prenatal alcohol exposure (PAE) and objective meconium alcohol markers to determine the optimal meconium marker and threshold for identifying PAE.
methodsMeconium fatty acid ethyl esters (FAEE), ethyl glucuronide (EtG), and ethyl sulfate (EtS) were quantified by LC-MS/MS in 0.1 g meconium from infants of Safe Passage Study participants. Detailed PAE information was collected from women with a validated timeline follow-back interview. Because meconium formation begins during weeks 12-20, maternal self-reported drinking at or beyond 19 weeks was our exposure variable.
resultsOf 107 women, 33 reported no alcohol consumption in pregnancy, 16 stopped drinking by week 19, and 58 drank beyond 19 weeks (including 45 third-trimester drinkers). There was moderate to substantial agreement between self-reported PAE at ≥19 weeks and meconium EtG ≥30 ng/g (κ = 0.57, 95% CI 0.41-0.73). This biomarker and associated cutoff was superior to a 7 FAEE sum ≥2 nmol/g and all other individual and combination marker cutoffs. With meconium EtG ≥30 ng/g as the gold standard condition and maternal self-report at ≥19 weeks' gestation as the test condition, 82% clinical sensitivity (95% CI 71.6-92.0) and 75% specificity (95% CI 63.2-86.8) were observed. A significant dose-concentration relationship between self-reported drinks per drinking day and meconium EtG ≥30 ng/g also was observed (all P < 0.01).
conclusionsMaternal alcohol consumption at ≥19 weeks was better represented by meconium EtG ≥30 ng/g than currently used FAEE cutoffs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.