ArticleEuropean journal of epidemiology2015
Association of coffee consumption and CYP1A2 polymorphism with risk of impaired fasting glucose in hypertensive patients.
Article in European journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- A Systematic Review of the Gene-Lifestyle Interactions on Metabolic Disease-Related Outcomes in Arab Populations.Nutrients · 2024Pooled it
- Dose-Response of Paraxanthine on Cognitive Function: A Double Blind, Placebo Controlled, Crossover Trial.Nutrients · 2021Trial
- Article
- Evaluating the effects of coffee consumption on the structure and function of the heart from multiple perspectives.Frontiers in cardiovascular medicine · 2025Article
- Sex Related Differences in the Complex Relationship between Coffee, Caffeine and Atrial Fibrillation.Nutrients · 2023Review
- CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction.JAMA network open · 2023Article
- Direct-to-Consumer Genetic Testing in Korea: Current Status and Significance in Clinical Nutrition.Clinical nutrition research · 2021Review
- Coffee and Arterial Hypertension.Current hypertension reports · 2021Review
- The relationship of coffee consumption and CVD risk factors in elderly patients with T2DM.BMC cardiovascular disorders · 2021Article
- International society of sports nutrition position stand: caffeine and exercise performance.Journal of the International Society of Sports Nutrition · 2021Review
- Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes.Archives of pharmacal research · 2021Review
- Habitual Coffee and Tea Consumption and Cardiometabolic Biomarkers in the UK Biobank: The Role of Beverage Types and Genetic Variation.The Journal of nutrition · 2020Article
- Mechanisms of action of coffee bioactive components on lipid metabolism.Food science and biotechnology · 2019Review
- Sport Nutrigenomics: Personalized Nutrition for Athletic Performance.Frontiers in nutrition · 2019Review
- Biases Inherent in Studies of Coffee Consumption in Early Pregnancy and the Risks of Subsequent Events.Nutrients · 2018Review
- Do genetics help epidemiologists? Arterial hypertension and cardiovascular events in the light of genetic demiology.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved.Advances in nutrition (Bethesda, Md.) · 2017Review
- Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence.Oxidative medicine and cellular longevity · 2017Review
- Effect of Coffee Consumption on the Progression of Type 2 Diabetes Mellitus among Prediabetic Individuals.Korean journal of family medicine · 2016Article
- Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake.Nutrition & metabolism · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether and how coffee use influences glucose metabolism is still a matter for debate. We investigated whether baseline coffee consumption is longitudinally associated with risk of impaired fasting glucose in a cohort of 18-to-45 year old subjects screened for stage 1 hypertension and whether CYP1A2 polymorphism modulates this association. A total of 1,180 nondiabetic patients attending 17 hospital centers were included. Seventy-four percent of our subjects drank coffee. Among the coffee drinkers, 87% drank 1-3 cups/day (moderate drinkers), and 13% drank over 3 cups/day (heavy drinkers). Genotyping of CYP1A2 SNP was performed by real time PCR in 639 subjects. At the end of a median follow-up of 6.1 years, impaired fasting glucose was found in 24.0% of the subjects. In a multivariable Cox regression coffee use was a predictor of impaired fasting glucose at study end, with a hazard ratio (HR) of 1.3 (95% CI 0.97-1.8) in moderate coffee drinkers and of 2.3 (1.5-3.5) in heavy drinkers compared to abstainers. Among the subjects stratified by CYP1A2 genotype, heavy coffee drinkers carriers of the slow *1F allele (59%) had a higher adjusted risk of impaired fasting glucose (HR 2.8, 95% CI 1.3-5.9) compared to abstainers whereas this association was of borderline statistical significance among the homozygous for the A allele (HR 1.7, 95% CI 0.8-3.8). These data show that coffee consumption increases the risk of impaired fasting glucose in hypertension particularly among carriers of the slow CYP1A2 *1F allele.
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