Observational studyBMC pulmonary medicine2015
Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation.
Observational study in BMC pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis.Respiratory research · 2018Pooled it
- Treatment Patterns and Triple Therapy Utilization in Chinese Patients with Chronic Obstructive Pulmonary Disease: An Analysis of Real-World Data from the Yinzhou Database.International journal of chronic obstructive pulmonary disease · 2025Article
- Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort.BMC pulmonary medicine · 2021Article
- Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts.The Lancet. Respiratory medicine · 2020Article
- Health-related quality of life of patients diagnosed with COPD in Extremadura, Spain: results from an observational study.Health and quality of life outcomes · 2019Observational
- Use of a Cross-Sectional Survey in the Adult Population to Characterize Persons at High-Risk for Chronic Obstructive Pulmonary Disease.Healthcare (Basel, Switzerland) · 2019Article
- Estimating Dementia and Receipt of Informal Care Using Behavioral Risk Factor Surveillance System Data.American journal of Alzheimer's disease and other dementias · 2017Article
- Undiagnosed chronic obstructive pulmonary disease in patients admitted to an acute assessment unit.European clinical respiratory journal · 2017Article
- Veterans Airflow Obstruction Screening Questionnaire: A Survey to Identify Veterans with Airflow Obstruction.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2016Article
- Risk stratification for COPD diagnosis through an active search strategy in primary care.International journal of chronic obstructive pulmonary disease · 2016Observational
- Assisted ventilation in COPD - association between previous hospitalizations and mortality.International journal of chronic obstructive pulmonary disease · 2016Article
- Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundUnder-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD.
methodsThe PAC-COPD cohort included 342 COPD patients hospitalised for the first time for an exacerbation of COPD (2004-2006). Patients were extensively characterised using sociodemographic, clinical and functional variables, and the cohort was followed-up through 2008. We defined "undiagnosed COPD" by the absence of any self-reported respiratory disease and regular use of any pharmacological respiratory treatment.
resultsUndiagnosed COPD was present in 34% of patients. They were younger (mean age 66 vs. 68 years, p = 0.03), reported fewer symptoms (mMRC dyspnoea score, 2.1 vs. 2.6, p < 0.01), and had a better health status (SGRQ total score, 29 vs. 40, p < 0.01), milder airflow limitation (FEV1% ref., 59% vs. 49%, p < 0.01), and fewer comorbidities (two or more, 40% vs. 56%, p < 0.01) when compared with patients with an established COPD diagnosis. Three months after hospital discharge, 16% of the undiagnosed COPD patients had stopped smoking (vs. 5%, p = 0.019). During follow-up, annual hospitalisation rates were lower in undiagnosed COPD patients (0.14 vs. 0.25, p < 0.01); however, this difference disappeared after adjustment for severity. Mortality was similar in both groups.
conclusionsUndiagnosed COPD patients have less severe disease and lower risk of re-hospitalisation when compared with hospitalised patients with known COPD.
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