ArticleVeterinary research2015
Effects of bovine leukemia virus infection on milk neutrophil function and the milk lymphocyte profile.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Impact of high proviral load on milk production, reproduction and subclinical diseases in dairy cows infected with bovine leukemia virus.Frontiers in veterinary science · 2025Article
- BLV-miR-B1-5p PromotesAnimals : an open access journal from MDPI · 2023Article
- Expression of Bovine Leukaemia Virus (BLV) Gp51 Protein in Blood and Milk Cells of Cows with Leukosis.Journal of veterinary research · 2022Article
- The effect of bovine leukemia virus on dairy cow longevity.JDS communications · 2022Article
- Brief Research Report: Expression of PD-1 and CTLA-4 in T Lymphocytes and Their Relationship With the Periparturient Period and the Endometrial Cytology of Dairy Cows During the Postpartum Period.Frontiers in veterinary science · 2022Article
- Cytokine TNF-α and its receptors TNFRI and TNFRII play a key role in the in vitro proliferative response of BLV infected animals.Veterinary research communications · 2021Article
- Milk lymphocyte profile and macrophage functions: new insights into the immunity of the mammary gland in quarters infected with Corynebacterium bovis.BMC veterinary research · 2021Article
- Dynamic changes in blood immune cell composition and function in Holstein and Jersey steers in response to heat stress.Cell stress & chaperones · 2021Article
- Milk Macrophage Function in Bovine Leukemia Virus-Infected Dairy Cows.Frontiers in veterinary science · 2021Article
- Effect of BLV Infection on the Immune Function of Polymorphonuclear Neutrophil in Dairy Cows.Frontiers in veterinary science · 2021Article
- Current Developments in the Epidemiology and Control of Enzootic Bovine Leukosis as Caused by Bovine Leukemia Virus.Pathogens (Basel, Switzerland) · 2020Review
- Association between bovine leukemia virus proviral load and severity of clinical mastitis.The Journal of veterinary medical science · 2019Article
- Genotyping bovine leukemia virus in dairy cattle of Heilongjiang, northeastern China.BMC veterinary research · 2019Article
- Potential roles of neutrophils in maintaining the health and productivity of dairy cows during various physiological and physiopathological conditions: a review.Immunologic research · 2019Review
- Development of an indirect ELISA based on recombinant capsid protein to detect antibodies to bovine leukemia virus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2018Article
- Incidence of mastitis and activity of milk neutrophils in Tharparkar cows reared under semi-arid conditions.Tropical animal health and production · 2016Article
- Flow Cytometry Approach to Quantify the Viability of Milk Somatic Cell Counts after Various Physico-Chemical Treatments.PloS one · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of bovine leukemia virus (BLV) on the immune response have been extensively investigated; however, its effects on mammary gland immunity are only speculative. Although BLV has a tropism for B cells, it can affect both adaptive and innate immunities because these systems share many effector mechanisms. This scenario is the basis of this investigation of the effects of BLV on mammary gland immunity, which is largely dependent upon neutrophilic functions. Thus, the present study sought to examine neutrophilic functions and the lymphocyte profile in the milk of naturally BLV-infected cows. The viability of the milk neutrophils and the percentage of milk neutrophils that produced reactive oxygen species (ROS) or phagocytosed Staphylococcus aureus were similar between BLV-infected and BLV-uninfected dairy cows. Furthermore, the expression of CD62L and CD11b by the milk neutrophils and the percentage of milk neutrophils (CH138+ cells) that were obtained from the udder quarters of the BLV-infected cows were not altered. Conversely, the median fluorescence intensity (MFI) representing intracellular ROS production and the phagocytosis of S. aureus, the expression of CD44 by the milk neutrophils and the percentage of apoptotic B cells were lower in the milk cells from BLV-infected dairy cows, particularly those from animals with persistent lymphocytosis (PL). The lymphocyte subsets were not different among the groups, with the exception of the percentage of CD5-/CD11b- B cells, which was higher in the milk cells from BLV-infected cows, particularly those with PL. Thus, the present study provides novel insight into the implications of BLV infection for mammary gland immunity.
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