ArticleEndocrinology2015
Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism.
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- G proteins of the GScience advances · 2025Article
- The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice.Molecular metabolism · 2024Article
- Article
- Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus.Endocrine reviews · 2022Review
- Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency.Molecular metabolism · 2021Article
- TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation.Scientific reports · 2021Article
- Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting.Nature neuroscience · 2021Article
- Female mice exposed to low doses of dioxin during pregnancy and lactation have increased susceptibility to diet-induced obesity and diabetes.Molecular metabolism · 2020Article
- Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice.Molecular metabolism · 2020Article
- Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells.Endocrinology · 2020Article
- Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer.PloS one · 2020Article
- Role of POMC and AgRP neuronal activities on glycaemia in mice.Scientific reports · 2019Article
- The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform.The Journal of comparative neurology · 2019Article
- POMC: The Physiological Power of Hormone Processing.Physiological reviews · 2018Review
- Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake.PLoS biology · 2018Article
- PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction.JCI insight · 2017Article
- Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity.FEBS letters · 2017Review
- Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.Molecular metabolism · 2017Article
- Article
- Oleate induces KNeuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Peptides derived from the proopiomelanocortin (POMC) precursor are critical for the normal regulation of many physiological parameters, and POMC deficiency results in severe obesity and metabolic dysfunction. Conversely, augmentation of central nervous system melanocortin function is a promising therapeutic avenue for obesity and diabetes but is confounded by detrimental cardiovascular effects including hypertension. Because the hypothalamic population of POMC-expressing neurons is neurochemically and neuroanatomically heterogeneous, there is interest in the possible dissociation of functionally distinct POMC neuron subpopulations. We used a Cre recombinase-dependent and hypothalamus-specific reactivatable PomcNEO allele to restrict Pomc expression to hypothalamic neurons expressing leptin receptor (Lepr) in mice. In contrast to mice with total hypothalamic Pomc deficiency, which are severely obese, mice with Lepr-restricted Pomc expression displayed fully normal body weight, food consumption, glucose homeostasis, and locomotor activity. Thus, Lepr+ POMC neurons, which constitute approximately two-thirds of the total POMC neuron population, are sufficient for normal regulation of these parameters. This functional dissociation approach represents a promising avenue for isolating therapeutically relevant POMC neuron subpopulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.