Trial reportInternational surgery2015
Plasma osteopontin predicts inflammatory bowel disease activities.
Trial report in International surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis.PloS one · 2018Trial
- Bone turnover markers in patients with inflammatory bowel disease in remission: a cross-sectional comparison of anti-TNFα therapy with conventional maintenance therapy.Frontiers in medicine · 2026Article
- Elevated osteopontin reflects systemic inflammation in experimental autoimmune encephalomyelitis.Anatomy & cell biology · 2025Article
- Evaluating osteopontin levels in pediatric celiac disease: a potential indicator for mucosal atrophy and osteoporosis.European journal of pediatrics · 2024Article
- The Role of Osteopontin in Psoriasis-A Scoping Review.Journal of clinical medicine · 2024Article
- Immunoregulatory Roles of Osteopontin in Diseases.Nutrients · 2024Review
- The Multifaceted Role of Osteopontin in Prostate Pathologies.Biomedicines · 2023Review
- The Role and Clinical Relevance of Osteopontin in Allergic Airway Diseases.Journal of clinical medicine · 2023Review
- Circulating Profile of ECM-Related Proteins as Diagnostic Markers in Inflammatory Bowel Diseases.Journal of clinical medicine · 2022Article
- Osteopontin in autoimmune disorders: current knowledge and future perspective.Inflammopharmacology · 2022Review
- Effects of Jian Pi Qing Chang Hua Shi decoction on mucosal injuries in a 2,4,6-trinitrobenzene sulphonic acid-induced inflammatory bowel disease rat model.Pharmaceutical biology · 2021Article
- Pathogenic Characterization ofFrontiers in microbiology · 2021Article
- A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory response in experimental colitis.Clinical and experimental immunology · 2019Article
- Bacteroides thetaiotaomicron Ameliorates Colon Inflammation in Preclinical Models of Crohn's Disease.Inflammatory bowel diseases · 2019Article
- Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.International journal of molecular sciences · 2017Article
- Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases.Journal of immunology research · 2016Review
- Osteopontin in Immune-mediated Diseases.Journal of dental research · 2015Review
- Current noninvasive modalities in Crohn's disease monitoring.Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A glycoprotein osteopontin (OPN) is involved in inflammatory diseases, but its roles in inflammatory bowel disease (IBD) are controversial. To analyze the involvement of the systemic immune response, we simultaneously examined plasma OPN levels and 17 cytokines. This study included 24 ulcerative colitis (UC) patients, 17 Crohn's disease (CD) patients, and 23 normal controls. Clinical parameters were also examined. The plasma OPN levels of the UC and CD patients were significantly higher than those of the normal controls and correlated significantly with their clinical activity indices. In the UC patients, significant relationships were observed between the levels of plasma OPN and multiple cytokines, including interleukin (IL) -1β, IL-4, IL-5, IL-6, IL-7, IL-13, interferon-γ, tumor necrosis factor-α, and granulocyte-macrophage colony-stimulating factor. In the CD patients, the correlation was not significant except for IL-8. Our findings reflect different inflammatory states of the colon and rectum in both diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.