Evidence map›Paper›PMID 25594599›Full record

ReviewSensors (Basel, Switzerland)2015

Design of surface modifications for nanoscale sensor applications.

Erik Reimhult, Fredrik Höök

Open access · goldAbstract readReview
In one paragraph

Review in Sensors (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 110 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  6. Review
  7. Article
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  9. Review
  10. Article
  11. Enhancement of Probe Density in DNA Sensing by Tuning the Exponential Growth Regime of Polyelectrolyte Multilayers.Chemistry of materials : a publication of the American Chemical Society · 2020
    Article
  12. Review
  13. Review
  14. Electrochemical Biosensors Based on S-Layer Proteins.Sensors (Basel, Switzerland) · 2020
    Review
  15. A Spellbinding Interplay Between Biological Barcoding and Nanotechnology.Frontiers in bioengineering and biotechnology · 2020
    Review
  16. Surface-Bound Antibiotic for the Detection of β-Lactamases.ACS applied materials & interfaces · 2019
    Article
  17. Review
  18. Review
  19. Review
  20. HNano convergence · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Erik ReimhultInstitute for Biologically Inspired Materials, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, A-1190 Vienna, Austria. erik.reimhult@boku.ac.at.
Fredrik HöökBiological Physics, Department of Applied Physics, Chalmers University of Technology, Fysikgränd 3, SE-411 33 Göteborg, Sweden. fredrik.hook@chalmers.se.
BOKU University · ATChalmers University of Technology · SE

Funding

European Research Council 310034
6 · The paper itself

Abstract

Nanoscale biosensors provide the possibility to miniaturize optic, acoustic and electric sensors to the dimensions of biomolecules. This enables approaching single-molecule detection and new sensing modalities that probe molecular conformation. Nanoscale sensors are predominantly surface-based and label-free to exploit inherent advantages of physical phenomena allowing high sensitivity without distortive labeling. There are three main criteria to be optimized in the design of surface-based and label-free biosensors: (i) the biomolecules of interest must bind with high affinity and selectively to the sensitive area; (ii) the biomolecules must be efficiently transported from the bulk solution to the sensor; and (iii) the transducer concept must be sufficiently sensitive to detect low coverage of captured biomolecules within reasonable time scales. The majority of literature on nanoscale biosensors deals with the third criterion while implicitly assuming that solutions developed for macroscale biosensors to the first two, equally important, criteria are applicable also to nanoscale sensors. We focus on providing an introduction to and perspectives on the advanced concepts for surface functionalization of biosensors with nanosized sensor elements that have been developed over the past decades (criterion (iii)). We review in detail how patterning of molecular films designed to control interactions of biomolecules with nanoscale biosensor surfaces creates new possibilities as well as new challenges.

Indexed as

Biosensing TechniquesEquipment DesignNanoparticlesSurface Properties

Identifiers

PMID25594599
PMCPMC4327096
OpenAlexW2014065889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.