ArticleCell2015
Identification and specification of the mouse skeletal stem cell.
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Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 488 papers.
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488citing papers in PubMed
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Who cites it
488 citing papers in PubMed.
- Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies.Regenerative therapy · 2026Review
- Skeletal stem and progenitor cell niche organization, regulation and repair.Reviews in endocrine & metabolic disorders · 2026Review
- Spatiotemporally programming the immune-osteogenic cascade with a dual-immunomodulatory scaffold for functional bone regeneration.Bioactive materials · 2026Article
- Unraveling stress fractures: from cellular and molecular mechanisms to therapeutic approaches.Journal of orthopaedic translation · 2026Review
- Fzd7 Restrains Pink1-Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Youthfulness of marrow AdipoqBone research · 2026Article
- Regional diversity of cranial skeletal stem cells governs bone morphogenetic protein-2 mediated bone regeneration.Nature communications · 2026Article
- Single-Cell Analyses Reveal Dysregulation of Ribosomal Protein Genes During Hematopoietic Stem and Progenitor Cell Aging.Advanced biology · 2026Article
- Low-intensity stimulation drives macrophage efferocytosis via ACSL4 lipid remodeling and CCL9-CCR1 signaling for tendon-bone healing.Science advances · 2026Article
- Clec3bBone research · 2026Article
- Article
- An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells.Bone research · 2026Article
- Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy.Advanced healthcare materials · 2026Review
- Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.Journal of periodontal research · 2026Review
- Intermittent parathyroid hormone employs autonomous and non-autonomous mechanisms to drive osteogenesis from Ebf3-expressing skeletal progenitor cells.bioRxiv : the preprint server for biology · 2026Article
- From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.Bone research · 2026Review
- A novel non-invasive approach monitoring skeletal stem cell function throughJournal of orthopaedic translation · 2026Article
- Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche.Bone research · 2026Review
- GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis.Nature communications · 2026Article
- Identification of Smmhc-expressing mesenchymal cells in orofacial bone at single-cell resolution.Bone research · 2026Article
428 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors.
Charles K F ChanDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA. Electronic address: chazchan@stanford.edu.
Eun Young SeoDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
James Y ChenDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
David LoDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Adrian McArdleDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Rahul SinhaDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Ruth TevlinDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Jun SeitaDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Justin Vincent-TompkinsDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Taylor WeardaDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Wan-Jin LuDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Kshemendra Senarath-YapaDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Michael T ChungDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Owen MarecicDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Misha TranDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Kelley S YanStanford Cancer Institute, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Rosalynd UptonDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Graham G WalmsleyDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Andrew S LeeDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Debashis SahooDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Calvin J KuoStanford Cancer Institute, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Irving L WeissmanDepartments of Pathology and Developmental Biology, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA.
Michael T LongakerDepartment of Surgery, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 450 Serra Mall, Palo Alto, CA 94305, USA. Electronic address: longaker@stanford.edu.
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8MLeveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1MInduced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2MInterrogation of individual cells to identify progenitors and their nichesU01HL099999 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2009 to 2015
$7.8MInterrogation of individual cells to identify progenitor cells and their nichesU01HL099995 · NHLBI · STANFORD UNIVERSITY · PI KRASNOW, MARK A · 2009 to 2015
$7.0MHSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionR01CA086065 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2000 to 2017
$6.9MRegulation of actively proliferating and quiescent intestinal stem cellsU01DK085527 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2009 to 2023
$6.9MIntestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5MHOMING RECEPTOR DETERMINANTS ON HSCR01HL058770 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 1998 to 2013
$3.9MLimited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3MCalvarial Regeneration using Biomatrix-Encapsulated Skeletal ProgenitorsRC2DE020771 · NIDCR · STANFORD UNIVERSITY · PI BARRON, ANNELISE EMILY, LONGAKER, MICHAEL T · 2009 to 2010
$2.1MOsteogenic Enrichment of Adipose Derived Stromal CellsR01DE021683 · NIDCR · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2012 to 2016
$2.0MNCI NIH HHS 1R01CA158528NCI NIH HHS R00 CA151673NCI NIH HHS R01 CA086065NCI NIH HHS R01 CA158528NCI NIH HHS R01 CA86065NHLBI NIH HHS R01 HL058770NHLBI NIH HHS U01 HL099776NHLBI NIH HHS U01 HL099995NHLBI NIH HHS U01 HL099999NHLBI NIH HHS U01HL099999NIDCR NIH HHS R01 DE019434NIDCR NIH HHS R01 DE021683NIDCR NIH HHS R01DE021683NIDCR NIH HHS R21 DE019274NIDCR NIH HHS R21 DE024230NIDCR NIH HHS RC2 DE020771NIDDK NIH HHS 2U01DK085527-06NIDDK NIH HHS K08 DK096048NIDDK NIH HHS K08 DK096048 01NIDDK NIH HHS U01 DK085527NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U24 DK085532NIGMS NIH HHS GM07365NIGMS NIH HHS NIHT32GM007365NIGMS NIH HHS T32 GM007365NINDS NIH HHS 1R01NS064517NINDS NIH HHS R01 NS064517
Abstract
How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment. We demonstrate that mSSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche factors can activate mSSC genetic programs in situ, even in nonskeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma. Inducing mSSC formation with soluble factors and subsequently regulating the mSSC niche to specify its differentiation toward bone, cartilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skeletal tissues.
Indexed as
AnimalsBone and BonesBone Morphogenetic ProteinsCartilageCell LineageCrosses, GeneticMesenchymal Stem CellsMiceMice, Inbred C57BLSignal TransductionBone Morphogenetic Proteins
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