Evidence map›Paper›PMID 25593952›Full record

ArticleFrontiers in surgery2014

Mid-Gestational Enlargement of Fetal Thalami in Women Exposed to Methadone during Pregnancy.

Meredith Schulson, Anthony Liu, Tracey Björkman, Ann Quinton, Kristy P Mann, Ron Benzie, Michael Peek, Ralph Nanan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. An Automated Framework for Large Scale Retrospective Analysis of Ultrasound Images.IEEE journal of translational engineering in health and medicine · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Meredith SchulsonDiscipline of Paediatrics, Sydney Medical School - Nepean, The University of Sydney , Penrith, NSW , Australia.
Anthony LiuDiscipline of Paediatrics, Sydney Medical School - Nepean, The University of Sydney , Penrith, NSW , Australia ; Charles Perkins Centre - Nepean, The University of Sydney , Penrith, NSW , Australia.
Tracey BjörkmanPerinatal Research Centre, UQ Centre for Clinical Research, The University of Queensland , Herston, QLD , Australia.
Ann QuintonCharles Perkins Centre - Nepean, The University of Sydney , Penrith, NSW , Australia ; Discipline of Obstetrics and Gynaecology, Sydney Medical School - Nepean, The University of Sydney , Penrith, NSW , Australia.
Kristy P MannNHMRC Clinical Trials Centre, The University of Sydney , Camperdown, NSW , Australia.
Ron BenzieDiscipline of Obstetrics and Gynaecology, Sydney Medical School - Nepean, The University of Sydney , Penrith, NSW , Australia.
Michael PeekCharles Perkins Centre - Nepean, The University of Sydney , Penrith, NSW , Australia ; Discipline of Obstetrics and Gynaecology, Sydney Medical School - Nepean, The University of Sydney , Penrith, NSW , Australia.
Ralph NananDiscipline of Paediatrics, Sydney Medical School - Nepean, The University of Sydney , Penrith, NSW , Australia ; Charles Perkins Centre - Nepean, The University of Sydney , Penrith, NSW , Australia.
University of Sydney · AUNepean Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methadone maintenance therapy is the standard of care in many countries for opioid-dependent women who become pregnant. Despite recent evidence showing significant neurodevelopmental changes in children and adults exposed to both licit and illicit substances in utero, data on the effects of opioids in particular remains scarce. The purpose of this study was to examine the effects of opiate use, in particular methadone, on various fetal cortical and biometric growth parameters in utero using ultrasound measurements done at 18-22 weeks gestation. Head circumference (HC), bi-parietal diameter, lateral ventricle diameter, transcerebellar diameter, thalamic diameter, cisterna magna diameter, and femur length were compared between fetuses born to methadone-maintained mothers and non-substance using controls. A significantly larger thalamic diameter (0.05 cm, p = 0.01) was observed in the opiate-exposed group. Thalamic diameter/HC ratio was also significantly raised (0.03 mm, p = 0.01). We hypothesize here that the increase in thalamic diameter in opiate-exposed fetuses could potentially be explained by regional differences in opioid and serotonin receptor densities, an alteration in monoamine neurotransmitter systems, and an enhancement of the normal growth increase that occurs in the thalamus during mid-gestation.

Indexed as

methadoneneurodevelopmentneuroimagingopiatespre-natal drug exposure

Identifiers

PMID25593952
PMCPMC4286970
OpenAlexW2155370205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.