Evidence map›Paper›PMID 25593863›Full record

ArticleAnnals of maxillofacial surgery

Induction of multinucleated giant cells in response to small sized bovine bone substitute (Bio-Oss™) results in an enhanced early implantation bed vascularization.

M Barbeck, S E Udeabor, J Lorenz, A Kubesch, J Choukroun, R A Sader, C J Kirkpatrick, S Ghanaati

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of maxillofacial surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 66 citations in OpenAlex.

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  6. Stabilization of Bio-OssFrontiers in bioengineering and biotechnology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

M BarbeckDepartment of Oral, Cranio Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany ; REPAIR Laboratory, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, D-55131 Mainz, Germany.
S E UdeaborREPAIR Laboratory, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, D-55131 Mainz, Germany.
J LorenzREPAIR Laboratory, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, D-55131 Mainz, Germany.
A KubeschDepartment of Oral, Cranio Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany ; REPAIR Laboratory, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, D-55131 Mainz, Germany.
J ChoukrounPain Clinic, 49 rue Gioffredo, 06000 Nice, France.
R A SaderREPAIR Laboratory, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, D-55131 Mainz, Germany.
C J KirkpatrickDepartment of Oral, Cranio Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany.
S GhanaatiDepartment of Oral, Cranio Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany ; REPAIR Laboratory, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, D-55131 Mainz, Germany.
Goethe University Frankfurt · DEJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe host tissue reaction to the xenogeneic bone substitute Bio-Oss™ (Geistlich Biomaterials, Wolhousen, Switzerland) was investigated focusing on the participating inflammatory cells and implantation bed vascularization. MATERIALS AND

methodsBio-Oss™ was implanted subcutaneously into CD1 mice for up to 60 days and analyzed by means of specialized histological and histomorphometrical techniques after explantation.

resultsBio-Oss™ induced within the first 15 days an early high vascularization combined with a marked presence of multinucleated giant cells. The latter cells were associated mainly with the smaller sized granules within the implantation bed. Toward the end of the study the number of multinucleated giant cells decreased while the tissue reaction to the larger granules was mainly mononuclear.

conclusionThe results of the present study showed that smaller xenogeneic bone substitute granules induce multinucleated giant cells, whereas the larger-sized ones became integrated within the implantation bed by means of a mononuclear cell-triggered granulation tissue. Obviously, the presence of multinucleated giant cells within biomaterial implantation beds is not only related to the type of synthetic bone substitute material, but also to the granule size of the natural-based xenogeneic bone substitute material.

Indexed as

Bio-Ossmultinucleated giant cellsvascularizationxenogeneic bone substitute

Identifiers

PMID25593863
PMCPMC4293834
OpenAlexW2133719031

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.