ReviewIranian Red Crescent medical journal2014
Hepatotoxicity of halogenated inhalational anesthetics.
Review in Iranian Red Crescent medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Perioperative drug management in non-critical companion animals: a retrospective study at a Spanish veterinary teaching hospital (2018-2022).The veterinary quarterly · 2025Article
- Sedative Agents, Synthetic Torpor, and Long-Haul Space Travel-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Monitoring of liver and kidney profiles in anesthesiologists working in a regional reference teaching hospital in Northern Italy: analysis of health surveillance data using a linear mixed model.International journal of occupational medicine and environmental health · 2024Article
- Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report.Anesthesia and pain medicine · 2024Article
- Postoperative liver injury after sevoflurane or propofol anesthesia in patients undergoing non-cardiac surgery: a retrospective cohort study.Scientific reports · 2024Article
- Nanotherapeutics for Alleviating Anesthesia-Associated Complications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Effect of fullerenol C60 on lung and renal tissue in lower extremity ischemia‑reperfusion injury in sevoflurane‑treated rats.Molecular medicine reports · 2024Article
- Fatal hepatotoxicity due to sevoflurane use in a paediatric patient after aortic repair: reality or fiction? A case of pharmacovigilance.European journal of hospital pharmacy : science and practice · 2023Article
- Anesthetic management with remimazolam in a patient with Child-Pugh C liver cirrhosis: a case report.JA clinical reports · 2022Article
- CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload.International journal of molecular sciences · 2021Review
- Drug class effects on respiratory mechanics in animal models: access and applications.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- What have we learned from animal models of idiosyncratic, drug-induced liver injury?Expert opinion on drug metabolism & toxicology · 2020Review
- Comparison of the Postoperative Liver Function Between Total Intravenous Anesthesia and Inhalation Anesthesia in Patients with Preoperatively Elevated Liver Transaminase Levels: A Retrospective Cohort Study.Therapeutics and clinical risk management · 2020Article
- Hepatotoxicity of anesthetic gases.EXCLI journal · 2020Article
- Toxic responses of the liver and kidneys following occupational exposure to anesthetic gases.EXCLI journal · 2020Article
- Sevoflurane exerts protective effects on liver ischemia/reperfusion injury by regulatingExperimental and therapeutic medicine · 2019Article
- Early, Subclinical Hematological Changes Associated with Occupational Exposure to High Levels of Nitrous Oxide.Toxics · 2018Article
- A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus.Case reports in obstetrics and gynecology · 2017Article
- [Hazard assessment and occupational safety measures in surgery : Relevant knowledge on occupational medicine].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Review
- The role of inhalational anesthetic drugs in patients with hepatic dysfunction: a review article.Anesthesiology and pain medicine · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextHalogenated inhalational anesthetics are currently the most common drugs used for the induction and maintenance of general anesthesia. Postoperative hepatic injury has been reported after exposure to these agents. Based on much evidence, mechanism of liver toxicity is more likely to be immunoallergic. The objective of this review study was to assess available studies on hepatotoxicity of these anesthetics. EVIDENCE ACQUISITION: We searched PubMed, Google Scholar, Scopus, Index Copernicus, EBSCO and the Cochrane Database using the following keywords: "inhalational Anesthetics" and "liver injury"; "inhalational anesthetics" and "hepatotoxicity"; "volatile anesthetics" and "liver injury"; "volatile anesthetics" and hepatotoxicity for the period of 1966 to 2013. Fifty two studies were included in this work.
resultsAll halogenated inhalational anesthetics are associated with liver injury. Halothane, enflurane, isoflurane and desflurane are metabolized through the metabolic pathway involving cytochrome P-450 2E1 (CYP2E1) and produce trifluoroacetylated components; some of which may be immunogenic. The severity of hepatotoxicity is associated with the degree by which they undergo hepatic metabolism by this cytochrome. However, liver toxicity is highly unlikely from sevoflurane as is not metabolized to trifluoroacetyl compounds.
conclusionsHepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature. Halothane-induced liver injury was extensively acknowledged; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity. Although anesthesia-induced hepatitis is not a common occurrence, we must consider the association between this disorder and the use of halogenated anesthetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.