ArticleVeterinary research forum : an international quarterly journal2013
The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.
Article in Veterinary research forum : an international quarterly journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory andGenes · 2022Article
- Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases.Cancers · 2022Review
- Photobiomodulation and B vitamins administration produces antinociception in an orofacial pain model through the modulation of glial cells and cytokines expression.Brain, behavior, & immunity - health · 2020Article
- Effects of intracerebroventricular injection of vitamin BVeterinary research forum : an international quarterly journal · 2018Article
- Effects of crocin and safranal, saffron constituents, on the formalin-induced orofacial pain in rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was performed to investigate the effects of long-term intraperitoneal (IP) injection of vitamin B12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. Neuropathic pain was induced by crush injury in right tibial nerve. Acetone spray and von Frey tests were used to obtain cold and mechanical allodynia responses, respectively, on day 11 after nerve crush. Normal saline, vitamin B12 and diclofenac were injected intraperitoneally for 10 consecutive days after surgery. Normal saline treated rats showed cold and mechanical allodynia responses after nerve crush. Vitamin B12 at doses of 50, 100 and 200 µg kg(-1) and diclofenac at a dose of 2 mg kg(-1) produced antiallodynic effects. Antiallodynic effects were not observed when subanalgesic doses of vitamin B12 (25 µg kg(-1)) and diclofenac (0.25 mg kg(-1)) were used together. By increasing the dose of vitamin B12 to an effective dose (100 µg kg(-1)), antiallodynic effects were observed when compared with diclofenac (0.25 mg kg(-1)) alone. The results indicated that vitamin B12 and diclofenac produced neuropathic pain suppressing effects. Moreover, a potentiation effect was observed between vitamin B12 and diclofenac.
Indexed as
Identifiers
25593681PMC4293892W1481684709What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.