Evidence map›Paper›PMID 25593469›Full record

ArticleWorld journal of gastroenterology2015

Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation.

Keigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Keigo SuetaniKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Chiaki OkuseKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Kazunari NakaharaKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Yosuke MichikawaKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Yohei NoguchiKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Midori SuzukiKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Ryo MoritaKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Nozomi SatoKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Masaki KatoKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
Fumio ItohKeigo Suetani, Chiaki Okuse, Kazunari Nakahara, Yosuke Michikawa, Yohei Noguchi, Midori Suzuki, Ryo Morita, Nozomi Sato, Masaki Kato, Fumio Itoh, Department of Gastroenterology and Hepatology, St. Marianna University, School of Medicine, Kawasaki 216-8511, Japan.
St. Marianna University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the need for thrombomodulin (rTM) therapy for disseminated intravascular coagulation (DIC) in patients with acute cholangitis (AC)-induced DIC.

methodsSixty-six patients who were diagnosed with AC-induced DIC and who were treated at our hospital were enrolled in this study. The diagnoses of AC and DIC were made based on the 2013 Tokyo Guidelines and the DIC diagnostic criteria as defined by the Japanese Association for Acute Medicine, respectively. Thirty consecutive patients who were treated with rTM between April 2010 and September 2013 (rTM group) were compared to 36 patients who were treated without rTM (before the introduction of rTM therapy at our hospital) between January 2005 and January 2010 (control group). The two groups were compared in terms of patient characteristics at the time of DIC diagnosis (including age, sex, primary disease, severity of cholangitis, DIC score, biliary drainage, and anti-DIC drugs), the DIC resolution rate, DIC score, the systemic inflammatory response syndrome (SIRS) score, hematological values, and outcomes. Using logistic regression analysis based on multivariate analyses, we also examined factors that contributed to persistent DIC.

resultsThere were no differences between the rTM group and the control group in terms of the patients' backgrounds other than administration. DIC resolution rates on day 9 were higher in the rTM group than in the control group (83.3% vs 52.8%, P < 0.01). The mean DIC scores on day 7 were lower in the rTM group than in the control group (2.1 ± 2.1 vs 3.5 ± 2.3, P = 0.02). The mean SIRS scores on day 3 were significantly lower in the rTM group than in the control group (1.1 ± 1.1 vs 1.8 ± 1.1, P = 0.03). Mortality on day 28 was 13.3% in the rTM group and 27.8% in the control group; these rates were not significantly different (P = 0.26). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC (P < 0.01, OR = 12, 95%CI: 2.3-60). Although the difference did not reach statistical significance, primary diseases (malignancies) (P = 0.055, OR = 3.9, 95%CI: 0.97-16) and the non-use of rTM had a tendency to be associated with persistent DIC (P = 0.08, OR = 4.3, 95%CI: 0.84-22).

conclusionThe add-on effects of rTM are anticipated in the treatment of AC-induced DIC, although biliary drainage for AC remains crucial.

Indexed as

DrainageAgedAged, 80 and overChi-Square DistributionCholangitisCombined Modality TherapyDisseminated Intravascular CoagulationFemaleHumansJapanLogistic ModelsMaleMultivariate AnalysisOdds RatioRetrospective StudiesThrombomodulinThrombomodulinAcute cholangitisAnticoagulant therapyBiliary drainageDisseminated intravascular coagulationThrombomodulin

Identifiers

PMID25593469
PMCPMC4292285
OpenAlexW1974571381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.