Evidence map›Paper›PMID 25593465›Full record

ArticleWorld journal of gastroenterology2015

Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: a case-control study in Korea.

Ban Seok Lee, Eun-Cheol Park, Seung Woo Park, Chung Mo Nam, Jaehoon Roh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  3. Viral hepatitis B and C infections increase the risks of intrahepatic and extrahepatic cholangiocarcinoma: Evidence from a systematic review and meta-analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020
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  14. [Study on Behavioral Factors Affecting the Risk of New HBV Infection among Diabetic Patients].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
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  20. Cholangiocarcinoma: a guide for the nonspecialist.International journal of general medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ban Seok LeeBan Seok Lee, Eun-Cheol Park, Seung Woo Park, Chung Mo Nam, Jaehoon Roh, Department of Medicine, Graduate School, Yonsei University College of Medicine, Seoul 120-752, South Korea.
Eun-Cheol ParkBan Seok Lee, Eun-Cheol Park, Seung Woo Park, Chung Mo Nam, Jaehoon Roh, Department of Medicine, Graduate School, Yonsei University College of Medicine, Seoul 120-752, South Korea.
Seung Woo ParkBan Seok Lee, Eun-Cheol Park, Seung Woo Park, Chung Mo Nam, Jaehoon Roh, Department of Medicine, Graduate School, Yonsei University College of Medicine, Seoul 120-752, South Korea.
Chung Mo NamBan Seok Lee, Eun-Cheol Park, Seung Woo Park, Chung Mo Nam, Jaehoon Roh, Department of Medicine, Graduate School, Yonsei University College of Medicine, Seoul 120-752, South Korea.
Jaehoon RohBan Seok Lee, Eun-Cheol Park, Seung Woo Park, Chung Mo Nam, Jaehoon Roh, Department of Medicine, Graduate School, Yonsei University College of Medicine, Seoul 120-752, South Korea.
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify possible risk factors and their synergism for cholangiocarcinoma development.

methodsA hospital-based, case-control study in which we included 276 cholangiocarcinoma patients [193 extrahepatic cholangiocarcinoma (ECC) and 83 intrahepatic cholangiocarcinoma (ICC)], diagnosed at a training hospital in Korea between 2007 and 2013, and 552 healthy controls matched 2:1 for age, sex, and date of diagnosis. Risk factors for cholangiocarcinoma and possible synergism between those factors were evaluated using conditional logistic regression and synergism index, respectively.

resultsThere was an association between cholangiocarcinoma and hepatitis B virus (HBV) infection, diabetes mellitus (DM), cholecystolithiasis, choledocholithiasis, and hepatolithiasis, with the adjusted odds ratios (AORs) of 4.1, 2.6, 1.7, 12.4, and 39.9, respectively. Synergistic interaction on the additive model was investigated between HBV infection and DM (AOR = 12.2; 95%CI: 1.9-80.1). In the subgroup analyses, cholecystolithiasis, choledocholithiasis, hepatolithiasis, and DM were significant risk factors for ECC (AOR = 2.0, 18.1, 14.9, and 2.0, respectively), whereas choledocholithiasis, hepatolithiasis, HBV infection, and DM were risk factors for ICC (AOR = 8.6, 157.4, 5.3 and 4.9, respectively). Synergistic interaction was also observed between HBV infection and DM (OR = 22.7; 95%CI: 2.4-214.1). However, there was no synergistic interaction between other significant risk factors for cholangiocarcinoma.

conclusionIn this Korean study, HBV infection and DM were found to exert independent and synergistic effects on the risk for cholangiocarcinoma, including ICC. Exploring the underlying mechanisms for such synergy may lead to the development of cholangiocarcinoma prevention strategies in high-risk individuals.

Indexed as

AgedAged, 80 and overBile Duct NeoplasmsBile Ducts, IntrahepaticCase-Control StudiesChi-Square DistributionCholangiocarcinomaDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHepatitis BHumansLogistic ModelsMaleMiddle AgedOdds RatioCholangiocarcinomaDiabetes mellitusHepatitisRisk factorSynergism

Identifiers

PMID25593465
PMCPMC4292281
OpenAlexW2106711606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.