ArticleAncient science of life
The effect of Macrotyloma uniflorum seed on bile lithogenicity against diet induced cholelithiasis on mice.
Article in Ancient science of life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 36 citations in OpenAlex.
- Effect ofSaudi journal of biological sciences · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe seeds of Macrotyloma uniflorum Lam. (Family Fabaceae) contain extractable total and tannins with reported hepatoprotective, hypocholesterolemic and antioxidant activity. In this study, dietary M. uniflorum seed, methanolic and acetone extracts (ME and AE) were examined for their bile-antilithogenic potential. MATERIALS AND
methodsMice fed with 1% cholesterol and 0.5% cholic acid lithogenic (LG) diet for 8 weeks resulted in cholesterol super saturation in gallbladder bile, which promotes the formation of cholesterol gallstones (CGSs).
resultsAE reduced the CGS incidence by 60.21%, and serum total cholesterol, triglyceride (TG), very low density lipoprotein (LDL) and LDL compared to control animals. Seed extracts at 300 mg/kg dose markedly reduced biliary cholesterol (BC) and decreased bile salt content. The ratio of BC to phospholipid which was 2.64 in the LG diet group was reduced to 1.57-1.35 in the M. uniflorum seed extracts treated groups. Liver cholesterol and TG were decreased significantly by feeding of ME and AE at 300 mg/kg dose. AE significantly reversed the changes in apolipoproteins A-I and C-II level disturbed by LG diet.
conclusionsM. uniflorum seed exerted antilithogenic influence by decreasing the cholesterol hyper-secretion into bile and increasing the bile acid output, thus decreasing the formation of LG bile in mice. The effect was maximum in the AE as it also reduced papillary proliferation of gallbladder and fatty degeneration of the liver. The potential antilithogenic effect of the AE of M. uniflorum may be due to antioxidant property of its rich total polyphenol and tannins content.
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