Evidence map›Paper›PMID 25593351›Full record

ArticlePlant physiology2015

ARACINs, Brassicaceae-specific peptides exhibiting antifungal activities against necrotrophic pathogens in Arabidopsis.

Jenny Neukermans, Annelies Inzé, Janick Mathys, Barbara De Coninck, Brigitte van de Cotte, Bruno P A Cammue, Frank Van Breusegem

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jenny NeukermansDepartment of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium (J.N., A.I., B.D.C., B.v.d.C., B.P.A.C., F.V.B.); Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (J.N., A.I., B.v.d.C., F.V.B.); andCentre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium (J.N., J.M., B.D.C, B.P.A.C.).
Annelies InzéDepartment of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium (J.N., A.I., B.D.C., B.v.d.C., B.P.A.C., F.V.B.); Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (J.N., A.I., B.v.d.C., F.V.B.); andCentre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium (J.N., J.M., B.D.C, B.P.A.C.).
Janick MathysDepartment of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium (J.N., A.I., B.D.C., B.v.d.C., B.P.A.C., F.V.B.); Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (J.N., A.I., B.v.d.C., F.V.B.); andCentre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium (J.N., J.M., B.D.C, B.P.A.C.).
Barbara De ConinckDepartment of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium (J.N., A.I., B.D.C., B.v.d.C., B.P.A.C., F.V.B.); Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (J.N., A.I., B.v.d.C., F.V.B.); andCentre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium (J.N., J.M., B.D.C, B.P.A.C.).
Brigitte van de CotteDepartment of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium (J.N., A.I., B.D.C., B.v.d.C., B.P.A.C., F.V.B.); Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (J.N., A.I., B.v.d.C., F.V.B.); andCentre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium (J.N., J.M., B.D.C, B.P.A.C.).
Bruno P A CammueDepartment of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium (J.N., A.I., B.D.C., B.v.d.C., B.P.A.C., F.V.B.); Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (J.N., A.I., B.v.d.C., F.V.B.); andCentre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium (J.N., J.M., B.D.C, B.P.A.C.) frank.vanbreusegem@psb.vib-ugent.be bruno.cammue@biw.vib-kuleuven.be.
Frank Van BreusegemDepartment of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium (J.N., A.I., B.D.C., B.v.d.C., B.P.A.C., F.V.B.); Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium (J.N., A.I., B.v.d.C., F.V.B.); andCentre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium (J.N., J.M., B.D.C, B.P.A.C.) frank.vanbreusegem@psb.vib-ugent.be bruno.cammue@biw.vib-kuleuven.be.
Ghent University · BEKU Leuven · BEVlaams Instituut voor Biotechnologie · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants have developed a variety of mechanisms to cope with abiotic and biotic stresses. In a previous subcellular localization study of hydrogen peroxide-responsive proteins, two peptides with an unknown function (designated ARACIN1 and ARACIN2) have been identified. These peptides are structurally very similar but are transcriptionally differentially regulated during abiotic stresses during Botrytis cinerea infection or after benzothiadiazole and methyl jasmonate treatments. In Arabidopsis (Arabidopsis thaliana), these paralogous genes are positioned in tandem within a cluster of pathogen defense-related genes. Both ARACINs are small, cationic, and hydrophobic peptides, known characteristics for antimicrobial peptides. Their genes are expressed in peripheral cell layers prone to pathogen entry and are lineage specific to the Brassicaceae family. In vitro bioassays demonstrated that both ARACIN peptides have a direct antifungal effect against the agronomically and economically important necrotrophic fungi B. cinerea, Alternaria brassicicola, Fusarium graminearum, and Sclerotinia sclerotiorum and yeast (Saccharomyces cerevisiae). In addition, transgenic Arabidopsis plants that ectopically express ARACIN1 are protected better against infections with both B. cinerea and A. brassicicola. Therefore, we can conclude that both ARACINs act as antimicrobial peptides.

Indexed as

AlternariaAmino Acid SequenceAntifungal AgentsAntimicrobial Cationic PeptidesArabidopsisBase SequenceBotrytisBrassicaceaeEndoplasmic ReticulumGene Expression Regulation, PlantGenes, PlantOrgan SpecificityPeptidesPhenotypePlant Growth RegulatorsPromoter Regions, GeneticAntifungal AgentsAntimicrobial Cationic PeptidesPeptidesPlant Growth Regulators

Identifiers

PMID25593351
PMCPMC4348783
OpenAlexW2156431782

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.