ArticlePlant physiology2015
Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed.
- Gene regulatory mechanisms downstream of DNA methylation.Nature reviews. Genetics · 2026Review
- An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics.Nature communications · 2025Article
- Genome-wide identification and expression analysis of the MBD gene family in Broomcorn millet (Panicum miliaceum) and its response to abiotic stress.BMC genomics · 2025Article
- An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics.bioRxiv : the preprint server for biology · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- The MBD-ACD DNA methylation reader complex recruits MICRORCHIDIA6 to regulate ribosomal RNA gene expression in Arabidopsis.The Plant cell · 2024Article
- Role of methylation in vernalization and photoperiod pathway: a potential flowering regulator?Horticulture research · 2023Article
- MBD3 Regulates Male Germ Cell Division and Sperm Fertility inPlants (Basel, Switzerland) · 2023Article
- The impacts of allopolyploidization on Methyl-CpG-Binding Domain (MBD) gene family in Brassica napus.BMC plant biology · 2022Article
- Fine mapping and characterization ofFrontiers in genetics · 2022Article
- Genome-Wide Characterization of the Methyl CpG Binding Domain-Containing Proteins in Watermelon and Functional Analysis of Their Roles in Disease Resistance Through Ectopic Overexpression inFrontiers in plant science · 2022Article
- AtHDA6 functions as an H3K18ac eraser to maintain pericentromeric CHG methylation in Arabidopsis thaliana.Nucleic acids research · 2021Article
- Biological role and mechanism of chromatin readers in plants.Current opinion in plant biology · 2021Review
- Overexpression of a methyl-CpG-binding protein gene OsMBD707 leads to larger tiller angles and reduced photoperiod sensitivity in rice.BMC plant biology · 2021Article
- Heterologous Expression ofGenes · 2020Article
- Hydrogen gas alleviates postharvest senescence of cut rose 'Movie star' by antagonizing ethylene.Plant molecular biology · 2020Article
- Involvement of MEM1 in DNA demethylation in Arabidopsis.Plant molecular biology · 2020Article
- H2A Variants inPlant communications · 2020Review
- METHIONINE SYNTHASE1 Is Involved in Chromatin Silencing by Maintaining DNA and Histone Methylation.Plant physiology · 2019Article
- Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
11 authors.
Chunlei WangState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Xiaomei DongState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Dan JinState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Yusheng ZhaoState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Shaojun XieState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Xiaojie LiState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Xinjian HeState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Zhaobo LangState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Jinsheng LaiState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Jian-Kang ZhuState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.).
Zhizhong GongState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences (C.W., D.J., Y.Z., X.L., Z.G.), State Key Laboratory of Agrobiotechnology (X.D., J.L.), and China National Maize Improvement Center, Department of Plant Genetics and Breeding (X.D., J.L.), China Agricultural University, Beijing 100193, China;Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47906 (S.X., Z.L., J.-K.Z.);National Institute of Biological Sciences, Beijing 102206, China (X.H.); andShanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China (J.-K.Z.) gongzz@cau.edu.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although researchers have established that DNA methylation and active demethylation are dynamically regulated in plant cells, the molecular mechanism for the regulation of active DNA demethylation is not well understood. By using an Arabidopsis (Arabidopsis thaliana) line expressing the Promoter RESPONSIVE TO DEHYDRATION 29A:LUCIFERASE (ProRD29A:LUC) and Promoter cauliflower mosaic virus 35S:NEOMYCIN PHOSPHOTRANSFERASE II (Pro35S:NPTII) transgenes, we isolated an mbd7 (for methyl-CpG-binding domain protein7) mutant. The mbd7 mutation causes an inactivation of the Pro35S:NPTII transgene but does not affect the expression of the ProRD29A:LUC transgene. The silencing of the Pro35S:NPTII reporter gene is associated with DNA hypermethylation of the reporter gene. MBD7 interacts physically with REPRESSOR OF SILENCING5/INCREASED DNA METHYLATION2, a protein in the small heat shock protein family. MBD7 prefers to target the genomic loci with high densities of DNA methylation around chromocenters. The Gypsy-type long terminal repeat retrotransposons mainly distributed around chromocenters are most affected by mbd7 in all transposons. Our results suggest that MBD7 is required for active DNA demethylation and antisilencing of the genomic loci with high densities of DNA methylation in Arabidopsis.
Indexed as
ArabidopsisArabidopsis ProteinsBase SequenceCloning, MolecularDNA-Binding ProteinsDNA MethylationGenome, PlantModels, BiologicalMolecular Sequence DataMutationProtein BindingArabidopsis ProteinsDNA-Binding ProteinsMBD7 protein, Arabidopsis
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