Evidence map›Paper›PMID 25593227›Full record

ArticleThe Journal of rheumatology2015

Elevation of serum immunoglobulin free light chains during the preclinical period of rheumatoid arthritis.

Xiaoli Deng, Cynthia S Crowson, S Vincent Rajkumar, Angela Dispenzieri, Dirk R Larson, Terry M Therneau, Eric L Matteson, Robert A Kyle, Jerry A Katzmann, Sherine E Gabriel and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

  1. Expression and diagnostic value of serum free light chain in lung cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  2. Article
  3. Free Light ChainsInternational journal of molecular sciences · 2023
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaoli DengFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Cynthia S CrowsonFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
S Vincent RajkumarFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Angela DispenzieriFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Dirk R LarsonFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Terry M TherneauFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Eric L MattesonFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Robert A KyleFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Jerry A KatzmannFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
Sherine E GabrielFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic.
John M DavisFrom the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. davis.john4@mayo.edu.
Peking University · CNPeking University Third Hospital · CN

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
HEART DISEASE IN RHEUMATOID ARTHRITISR01AR046849 · NIAMS · MAYO CLINIC ROCHESTER · PI CROWSON, CYNTHIA S · 2000 to 2022
$11.3M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Prevalence and Progression of Monoclonal GammopathiesR01CA107476 · NCI · MAYO CLINIC ROCHESTER · PI KUMAR, SHAJI KUNNATHU, RAJKUMAR, S VINCENT · 2004 to 2018
$4.6M
Onset and biomarkers for progression of monoclonal gammopathiesR01CA168762 · NCI · MAYO CLINIC ROCHESTER · PI KUMAR, SHAJI KUNNATHU, RAJKUMAR, S VINCENT · 2012 to 2024
$3.2M
NCATS NIH HHS UL1 TR000135NCI NIH HHS CA107476NCI NIH HHS CA168762NCI NIH HHS R01 CA107476NCI NIH HHS R01 CA168762NIAMS NIH HHS R01 AR046849NIAMS NIH HHS R01 AR46849NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

objectiveImmunoglobulin free light chains (FLC) represent biomarkers of B cell activity in rheumatoid arthritis (RA) and are associated with all-cause mortality in the general population. Our objective was to evaluate the relationships of serum FLC to preclinical disease, RA characteristics, and mortality in RA compared to non-RA subjects.

methodsA population-based study in Olmsted County, Minnesota, USA, was performed by crosslinking a large cohort in the general population having available serum FLC measurements with established RA incidence and prevalence cohorts. Serum κ, λ, and total FLC and their trends relative to RA incidence were compared between RA and non-RA subjects. Regression models were used to determine the associations between FLC, disease characteristics, and mortality, testing for differential effects of FLC on mortality in RA.

resultsAmong 16,609 subjects, 270 fulfilled the criteria for RA at the time of FLC measurement. Mean total FLC were significantly higher in RA compared to non-RA subjects (4.2 vs 3.3 mg/dl, p < 0.001). FLC became elevated 3-5 years before the clinical onset of RA and remained elevated during followup. Polyclonal FLC were found to predict higher mortality in persons with RA, though elevation to the highest decile had a relatively lower effect on mortality in RA compared to non-RA subjects.

conclusionElevation of serum FLC precedes the development of RA and may be useful in monitoring B cell activity and disease progression. FLC are associated with mortality among patients with RA as well as the general population.

Indexed as

AgedArthritis, RheumatoidDisease ProgressionFemaleHumansImmunoglobulin Light ChainsIncidenceMaleMiddle AgedMinnesotaPrevalenceProdromal SymptomsImmunoglobulin Light ChainsAUTOIMMUNITYB CELLBIOMARKERSMORTALITY

Identifiers

PMID25593227
PMCPMC4371213
OpenAlexW2318863492

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