Evidence map›Paper›PMID 25593135›Full record

Trial reportStroke2015

Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis.

Helmi L Lutsep, Stanley L Barnwell, Darren T Larsen, Michael J Lynn, Mindy Hong, Tanya N Turan, Colin P Derdeyn, David Fiorella, L Scott Janis, Marc I Chimowitz and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00576693 (Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00576693 phase3completednot on this map

Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis

TypeinterventionalSponsorMedical University of South CarolinaRan2008 to 2013Enrolled451ConditionsIschemic StrokeArmsintracranial angioplasty and stenting, intensive medical management
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Management of Symptomatic Intracranial Stenosis.Current cardiology reports · 2016
    Review
  10. China Angioplasty and Stenting for Symptomatic Intracranial Severe Stenosis (CASSISS): A new, prospective, multicenter, randomized controlled trial in China.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2015
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Helmi L LutsepFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.). lutseph@ohsu.edu.
Stanley L BarnwellFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
Darren T LarsenFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
Michael J LynnFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
Mindy HongFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
Tanya N TuranFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
Colin P DerdeynFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
David FiorellaFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
L Scott JanisFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
Marc I ChimowitzFrom the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).
SAMMPRIS Investigators

Funding

SAMMPRIS (Stenting vs. Aggressive Medical Management for Preventing . . .U01NS058728 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHIMOWITZ, MARC IVOR · 2008 to 2011
$20.0M
P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI GROSSNIKLAUS, HANS E. · 1986 to 2025
$15.3M
Coordinating Center for Infant Aphakia Treatment Study (IATS)U10EY013287 · NEI · EMORY UNIVERSITY · PI LONG, QI · 2004 to 2014
$5.8M
Coordinating Center for Infant Aphakia Treatment Study (IATS)UG1EY013287 · NEI · EMORY UNIVERSITY · PI NIZAM, AZHAR · 2015 to 2018
$917k
Characterization of Intracranial Atherosclerotic Stenosis Using HR MRIK23NS069668 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TURAN, TANYA N · 2011 to 2015
$903k
NEI NIH HHS P30 EY006360NEI NIH HHS U10 EY013287NEI NIH HHS UG1 EY013287NINDS NIH HHS K23 NS069668NINDS NIH HHS U01 NS058728
6 · The paper itself

Abstract

background and purposeStenting has been used as a rescue therapy in patients with intracranial arterial stenosis and a transient ischemic attack or stroke when on antithrombotic therapy (AT). We determined whether the stenting versus aggressive medical therapy for intracranial arterial stenosis (SAMMPRIS) trial supported this approach by comparing the treatments within subgroups of patients whose qualifying event (QE) occurred on versus off of AT.

methodsThe primary outcome, 30-day stroke and death and later strokes in the territory of the qualifying artery, was compared between (1) percutaneous transluminal angioplasty and stenting plus aggressive medical therapy (PTAS) versus aggressive medical management therapy alone (AMM) for patients whose QE occurred on versus off AT and between (2) patients whose QE occurred on versus off AT separately for the treatment groups.

resultsAmong the 284/451 (63%) patients who had their QE on AT, the 2-year primary end point rates were 15.6% for those randomized to AMM (n=140) and 21.6% for PTAS (n=144; P=0.043, log-rank test). In the 167 patients not on AT, the 2-year primary end point rates were 11.6% for AMM (n=87) and 18.8% for PTAS (n=80; P=0.31, log-rank test). Within both treatment groups, there was no difference in the time to the primary end point between patients who were on or off AT (AMM, P=0.96; PTAS, P=0.52; log-rank test).

conclusionsSAMMPRIS results indicate that the benefit of AMM over PTAS is similar in patients on versus off AT at the QE and that failure of AT is not a predictor of increased risk of a primary end point. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00576693.

Indexed as

Data Interpretation, StatisticalStentsAgedAngioplastyConstriction, PathologicDrug Therapy, CombinationFemaleFibrinolytic AgentsHumansIntracranial ArteriosclerosisIschemic Attack, TransientMaleMiddle AgedTreatment OutcomeFibrinolytic Agentsantiplatelet agentsintracranial arteriosclerosisstroke

Identifiers

PMID25593135
PMCPMC4342339

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.