Evidence map›Paper›PMID 25593060›Full record

ReviewJournal of the American College of Cardiology2015

Remote ischemic conditioning.

Gerd Heusch, Hans Erik Bøtker, Karin Przyklenk, Andrew Redington, Derek Yellon

5 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 312 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
312citing papers in PubMed, 10 pooled it
59.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03010839 nacompletednot on this mapstarted 2016, after this paper: background citation

Cardiopulmonary Protection of Modified Remote Ischaemic Preconditioning in Mitral Valve Replacement Surgery

TypeinterventionalSponsorXuzhou Medical UniversityRan2016 to 2018Enrolled86ConditionsMyocardial Injury, Remote Ischemic PreconditioningArmsModified Remote Ischemic Preconditioning, Control
NCT03016182 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Effect of Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery

TypeinterventionalSponsorXuzhou Medical UniversityRan2017 to 2018Enrolled60ConditionsLung Injury, Remote Ischemic PreconditioningArmsRemote Ischemic Preconditioning, Control
NCT03375762 naunknown statusnot on this mapstarted 2019, after this paper: background citation

REMOTE Ischemic Perconditioning Among Acute Ischemic Stroke Patients in CATalonia: REMOTE-CAT PROJECT

TypeinterventionalSponsorInstitut de Recerca Biomèdica de LleidaRan2019 to 2024Enrolled572ConditionsIschemic StrokeArmsRemote ischemic perconditioning, Sham remote perconditioning
NCT04284592 nacompletednot on this map

Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery: a Randomised Controlled Study

TypeinterventionalSponsorJosé García de la AsunciónRan2012 to 2017Enrolled70ConditionsIschemia-reperfusion InjuryArmsRemote ischemic post-conditioning (RIP)
NCT05230966 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Immunometabolic Pattern of Intermittent Hypoxia as a Protective Mechanism Against Lethal Reperfusion Injury in Patients With ST-segment Elevation Myocardial Infarction

TypeinterventionalSponsorClinical Hospital Center RijekaRan2022 to 2023Enrolled25ConditionsMyocardial Ischemic-reperfusion InjuryArmsRemote Ischemic Conditioning (RIC)
3 · Its place in the literature

Who cites it

312 citing papers in PubMed, 10 syntheses or guidelines pooled it, 617 citations in OpenAlex.

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  18. The effect of repeated remote ischemic postconditioning after an ischemic stroke (REPOST): A randomized controlled trial.International journal of stroke : official journal of the International Stroke Society · 2023
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252 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Gerd HeuschInstitute for Pathophysiology, West German Heart and Vascular Centre Essen, University of Essen Medical School, Essen, Germany. Electronic address: gerd.heusch@uk-essen.de.
Hans Erik BøtkerDepartment of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark.
Karin PrzyklenkCardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan.
Andrew RedingtonHospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Derek YellonThe Hatter Cardiovascular Institute, University College London, London, United Kingdom.
Aarhus University Hospital · DKUniversity College London · GBUniversity of Toronto · CAWayne State University · USWest German Heart and Vascular Center Essen · DE

Funding

Preconditioning Improves Coronary PatencyR01HL072684 · NHLBI · WAYNE STATE UNIVERSITY · PI PRZYKLENK, KARIN · 2002 to 2012
$2.2M
Preconditioning Improves Coronary PatencyR56HL072684 · NHLBI · WAYNE STATE UNIVERSITY · PI PRZYKLENK, KARIN · 2007 to 2007
$394k
British Heart Foundation RG/08/015/26411Medical Research Council MR/K002066/1NHLBI NIH HHS HL072684NHLBI NIH HHS R01 HL072684NHLBI NIH HHS R56 HL072684
6 · The paper itself

Abstract

In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury. The peripheral stimulus can be chemical, mechanical, or electrical and involves activation of peripheral sensory nerves. The signal transfer to the heart or other organs is through neuronal and humoral communications. Protection can be transferred, even across species, with plasma-derived dialysate and involves nitric oxide, stromal derived factor-1α, microribonucleic acid-144, but also other, not yet identified factors. Intracardiac signal transduction involves: adenosine, bradykinin, cytokines, and chemokines, which activate specific receptors; intracellular kinases; and mitochondrial function. RIC by repeated brief inflation/deflation of a blood pressure cuff protects against endothelial dysfunction and myocardial injury in percutaneous coronary interventions, coronary artery bypass grafting, and reperfused acute myocardial infarction. RIC is safe and effective, noninvasive, easily feasible, and inexpensive.

Indexed as

AnimalsCoronary CirculationHumansIschemic Preconditioning, MyocardialMyocardial Reperfusion Injuryacute myocardial infarctioncoronary artery bypass graftingmyocardial ischemiareperfusion

Identifiers

PMID25593060
PMCPMC4297315
OpenAlexW2012517632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.