ArticleBMC medicine2015
Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study.
Article in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review.BMC cancer · 2019Pooled it
- ABO Blood Types and Mortality in Patients Undergoing Hemodialysis.Kidney international reports · 2026Article
- ABO blood group and Rhesus factor as potential markers in papillary thyroid cancer: a retrospective comparative analysis (2015-2023).Langenbeck's archives of surgery · 2025Article
- Differences in outcomes associated with ABO blood groups in recipients of IVIG.Blood vessels, thrombosis & hemostasis · 2025Article
- ABO/rhesus D blood systems and health indices: a preliminary study to find an association among healthy dwellers of Anuradhapura, Sri Lanka.BMC research notes · 2025Article
- Investigation of unfavorable prognostic factors for survival in Chinese patients with gastric gastrointestinal stromal tumors.Translational cancer research · 2024Article
- Mendelian randomization combined with multi-omics explores the relationship between heart failure and cancer.Journal of Cancer · 2024Article
- Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation.Journal of thrombosis and haemostasis : JTH · 2023Article
- Haplotype sequence collection of ABO blood group alleles by long-read sequencing reveals putative A1-diagnostic variants.Blood advances · 2023Article
- Galectin-3 and Blood Group: Binding Properties, Effects on Plasma Levels, and Consequences for Prognostic Performance.International journal of molecular sciences · 2023Article
- A phenome-wide association study of ABO blood groups.BMC medicine · 2020Article
- Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis.New microbes and new infections · 2020Article
- Possible Link Between the ABO Blood Group of Bioprosthesis Recipients and Specific Types of Structural Degeneration.Journal of the American Heart Association · 2020Article
- Article
- Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses.EBioMedicine · 2019Article
- The relationship between platelet indices and ABO blood groups in healthy adults.Journal of clinical laboratory analysis · 2019Article
- Prospective Epidemiological Research Studies in Iran (the PERSIAN Cohort Study): Rationale, Objectives, and Design.American journal of epidemiology · 2018Article
- ABO histo-blood group and risk of respiratory atopy in children: a review of published evidence.Pediatric health, medicine and therapeutics · 2018Review
- Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project.Blood advances · 2016Article
- The prognostic value of ABO blood group in cancer patients.Blood transfusion = Trasfusione del sangue · 2016Review
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11 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundA few studies have shown an association between blood group alleles and vascular disease, including atherosclerosis, which is thought to be due to the higher level of von Willebrand factor in these individuals and the association of blood group locus variants with plasma lipid levels. No large population-based study has explored this association with overall and cause-specific mortality.
methodsWe aimed to study the association between ABO blood groups and overall and cause-specific mortality in the Golestan Cohort Study. In this cohort, 50,045 people 40- to 70-years old were recruited between 2004 and 2008, and followed annually to capture all incident cancers and deaths due to any cause. We used Cox regression models adjusted for age, sex, smoking, socioeconomic status, ethnicity, place of residence, education and opium use.
resultsDuring a total of 346,708 person-years of follow-up (mean duration 6.9 years), 3,623 cohort participants died. Non-O blood groups were associated with significantly increased total mortality (hazard ratio (HR) = 1.09; 95% confidence interval (CI): 1.01 to 1.17) and cardiovascular disease mortality (HR = 1.15; 95% CI: 1.03 to 1.27). Blood group was not significantly associated with overall cancer mortality, but people with group A, group B, and all non-O blood groups combined had increased risk of incident gastric cancer. In a subgroup of cohort participants, we also showed higher plasma total cholesterol and low-density lipoprotein (LDL) in those with blood group A.
conclusionsNon-O blood groups have an increased mortality, particularly due to cardiovascular diseases, which may be due to the effect of blood group alleles on blood biochemistry or their effect on von Willebrand factor and factor VIII levels.
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