ArticleNature communications2015
Quorum sensing triggers the stochastic escape of individual cells from Pseudomonas putida biofilms.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application.Gut microbes · 2026Review
- Microbial quorum sensing signals, symbiosis, secrets and sabotage.Microbiology (Reading, England) · 2026Review
- Single-cell phenotypic heterogeneity shapes quorum signaling dynamics in Pseudomonas aeruginosa.Nature communications · 2026Article
- Genome-mining revealed biosurfactant production capacity and gene co-occurrence patterns in diverse ecosystems.Microbial cell factories · 2026Article
- Lives in a gram of soil: linking life cycle biology to soil ecology.The ISME journal · 2026Review
- Pseudomonadota bridge cross-trophic interactions to suppress plant pathogens.The ISME journal · 2026Article
- High-resolution visualization of biofilm matrix development in space and time using fluorescent stains for cellulose.NPJ biofilms and microbiomes · 2026Article
- Decoding the spatiotemporal heterogeneity of bacterial virulence gene expression using single-cell approaches.Frontiers in microbiology · 2026Review
- Lineage-restricted genomic islands drive rhizosphere niche specialization inISME communications · 2026Article
- Diverse quorum sensing systems regulate microbial communication and biogeochemical processes in deep-sea cold seeps.Microbiome · 2025Article
- Article
- Biofilms as more than the sum of their parts: lessons from developmental biology.Current opinion in microbiology · 2024Review
- Single-cell level LasR-mediated quorum sensing response of Pseudomonas aeruginosa to pulses of signal molecules.Scientific reports · 2024Article
- Quorum sensing-related activities of beneficial and pathogenic bacteria have important implications for plant and human health.FEMS microbiology ecology · 2024Review
- Article
- Interspecific competition prevents the proliferation of social cheaters in an unstructured environment.The ISME journal · 2024Article
- Spatial structure, chemotaxis and quorum sensing shape bacterial biomass accumulation in complex porous media.Nature communications · 2024Article
- Quorum sensing going wild.iScience · 2023Review
- Navigating Environmental Transitions: the Role of Phenotypic Variation in Bacterial Responses.mBio · 2022Review
- MALDI Mass Spectrometry Imaging Reveals the Existence of anMetabolites · 2022Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The term 'quorum sensing' (QS) is generally used to describe the phenomenon that bacteria release and perceive signal molecules to coordinate cooperative behaviour in response to their population size. QS-based communication has therefore been considered a social trait. Here we show that QS signals (N-acyl-homoserine lactones, AHLs) are stochastically produced in young biofilms of Pseudomonas putida and act mainly as self-regulatory signals rather than inducing neighbouring cells. We demonstrate that QS induces the expression of putisolvin biosurfactants that are not public goods, thereby triggering asocial motility of induced cells out of microcolonies. Phenotypic heterogeneity is most prominent in the early stages of biofilm development, whereas at later stages behaviour patterns across cells become more synchronized. Our findings broaden our perspective on QS by showing that AHLs can control the expression of asocial (self-directed) traits, and that heterogeneity in QS can serve as a mechanism to drive phenotypic heterogeneity in self-directed behaviour.
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