ArticleDigestive diseases and sciences2015
Chronic hepatitis C infection as a risk factor for renal cell carcinoma.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- The association between hepatitis C virus infection and renal cell cancer, prostate cancer, and bladder cancer: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review.World journal of gastroenterology · 2015Pooled it
- Global patterns and trends in kidney cancer incidence and mortality.International journal of cancer · 2026Article
- Article
- The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons.Pathogens (Basel, Switzerland) · 2022Review
- Renal cell carcinoma and viral infections: A dangerous relationship?World journal of nephrology · 2022Review
- Epidemiology of Renal Cell Carcinoma.European urology · 2019Review
- Global epidemiology and burden of HCV infection and HCV-related disease.Nature reviews. Gastroenterology & hepatology · 2017Review
- Hepatitis C Virus and Nonliver Solid Cancers: Is There an Association between HCV and Cancers of the Pancreas, Thyroid, Kidney, Oral Cavity, Breast, Lung, and Gastrointestinal Tract?Gastroenterology research and practice · 2017Review
- Hepatitis C infection and renal cell carcinoma: A systematic review and meta-analysis.World journal of gastrointestinal pathophysiology · 2016Article
- Prevalence of Renal Impairment and Associated Conditions Among HCV-Infected Persons in the Chronic Hepatitis Cohort Study (CHeCS).Digestive diseases and sciences · 2016Article
- Extrahepatic manifestations of hepatitis C infection: navigating CHASM.Current HIV/AIDS reports · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic hepatitis C virus (HCV) infection causes cirrhosis and hepatocellular carcinoma but is also etiologically linked to several extrahepatic medical conditions including renal disorders. HCV is also associated with extrahepatic malignancies and may be oncogenic. Whether HCV confers an increased risk of renal cell carcinoma (RCC) remains controversial.
aimsProspectively determine whether chronic HCV is associated with an increased risk of RCC.
methodsAt an integrated medical center in Detroit, Michigan, adult patients with suspected RCC or newly diagnosed colon cancer (controls) were screened for hepatitis C antibody (HCAB) and HCV RNA. Renal or colon cancers were confirmed histologically. The proportion of patients with HCAB and HCV RNA in each group was compared, and risk factors for renal cell carcinoma were determined by multivariable logistic regression analysis.
resultsRCC patients had a higher rate of HCAB positivity (11/140, 8 %) than colon cancer patients (1/100, 1 %) (p < 0.01). Of the HCAB-positive patients, 9/11 RCC and 0/1 controls had detectable HCV RNA. HCV RNA positivity was a significant risk factor for RCC (OR 24.20; 95 % CL 2.4, >999.9; p = 0.043). Additionally, viremic RCC patients were significantly younger than RCC patients who were HCV RNA negative (p = 0.013).
conclusionsPatients with chronic HCV are at heightened risk of RCC.
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