ArticlePacific Symposium on Biocomputing. Pacific Symposium on Biocomputing2015
Development of exposome correlation globes to map out environment-wide associations.
Article in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Design and methodology challenges of environment-wide association studies: A systematic review.Environmental research · 2020Pooled it
- Vitamin D supplementation to improve pregnancy and perinatal outcomes: an overview of 42 systematic reviews.BMJ open · 2020Pooled it
- Field-wide meta-analyses of observational associations can map selective availability of risk factors and the impact of model specifications.Journal of clinical epidemiology · 2016Pooled it
- Integrating omics and artificial intelligence in pediatric environmental health: tools, challenges, and cohort-based insights.Pediatric research · 2026Review
- Vision for Exposomics-Scale Investigation: A Heuristic for Exposure-Wide Association Studies (ExWAS).Environmental science & technology · 2026Review
- Radiologic exposomics: imaging the environmental imprint on cancer for precision oncology.La Radiologia medica · 2026Review
- Bridging the life-course exposome approach with a life-cycle perspective in safe and sustainable by design (SSbD) for chemical risk.Human genomics · 2026Article
- An atlas of exposome-phenome associations in health and disease risk.Nature medicine · 2026Article
- Identifying direct risk factors in UK Biobank via simultaneous Bayesian-frequentist model-averaged hypothesis testing using Doublethink.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Influence of Sleep and Diet on Human Peripheral Immunity and Chronic Health Conditions.Research (Washington, D.C.) · 2026Article
- Population epigenetics: Historical notes and applications in human health.Genetics and molecular biology · 2026Article
- Uncovering Exposure Patterns of Metals, PFAS, Phthalates, and PAHs and Their Combined Effect on Liver Injury Markers.Journal of xenobiotics · 2025Article
- Decoding the Foodome: Molecular Networks Connecting Diet and Health.Annual review of nutrition · 2024Review
- Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).Exposome · 2024Article
- Article
- Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors.Nature communications · 2023Article
- Optimizing human performance in extreme environments through precision medicine: From spaceflight to high-performance operations on Earth.Cambridge prisms. Precision medicine · 2023Review
- GlobeCorr: interactive globe-based visualization for correlation datasets.Bioinformatics advances · 2023Article
- Exposure modelling in Europe: how to pave the road for the future as part of the European Exposure Science Strategy 2020-2030.Journal of exposure science & environmental epidemiology · 2022Review
- Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery.Environmental health perspectives · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The environment plays a major role in influencing diseases and health. The phenomenon of environmental exposure is complex and humans are not exposed to one or a handful factors but potentially hundreds factors throughout their lives. The exposome, the totality of exposures encountered from birth, is hypothesized to consist of multiple inter-dependencies, or correlations, between individual exposures. These correlations may reflect how individuals are exposed. Currently, we lack methods to comprehensively identify robust and replicated correlations between environmental exposures of the exposome. Further, we have not mapped how exposures associated with disease identified by environment-wide association studies (EWAS) are correlated with other exposures. To this end, we implement methods to describe a first "exposome globe", a comprehensive display of replicated correlations between individual exposures of the exposome. First, we describe overall characteristics of the dense correlations between exposures, showing that we are able to replicate 2,656 correlations between individual exposures of 81,937 total considered (3%). We document the correlation within and between broad a priori defined categories of exposures (e.g., pollutants and nutrient exposures). We also demonstrate utility of the exposome globe to contextualize exposures found through two EWASs in type 2 diabetes and all-cause mortality, such as exposure clusters putatively related to smoking behaviors and persistent pollutant exposure. The exposome globe construct is a useful tool for the display and communication of the complex relationships between exposure factors and between exposure factors related to disease status.
Indexed as
Identifiers
25592584PMC4299925W1983950597What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.