Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
Arthur M Feldman, Lilin She, Dennis M McNamara, Douglas L Mann, Michael R Bristow, Alan S Maisel, Daniel R Wagner, Bert Andersson, Luigi Chiariello, Christopher S Hayward and 10 more
Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
Trial report in Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it
What it found
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2 · The registry
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3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
Arthur M FeldmanDepartment of Medicine, Temple University School of Medicine, Philadelphia, Pa., USA.
Lilin She
Dennis M McNamara
Douglas L Mann
Michael R Bristow
Alan S Maisel
Daniel R Wagner
Bert Andersson
Luigi Chiariello
Christopher S Hayward
Paul Hendry
John D Parker
Normand Racine
Craig H Selzman
Michele Senni
Janina Stepinska
Marian Zembala
Jean Rouleau
Eric J Velazquez
Kerry L Lee
Duke University · USInstitute of Cardiology · PLUniversité de Montréal · CAAzienda Ospedaliero Universitaria Ospedali Riuniti · ITMedical University of Silesia · PLSacred Heart University · LUSt Vincent's Hospital Sydney · AUTemple University · USUniversity Health Network · CAUniversity of California, San Diego · USUniversity of Colorado Denver · USUniversity of Gothenburg · SEUniversity of Ottawa · CAUniversity of Pittsburgh · US
Funding
STICH Trial-Coordinating CenterU01HL069015 · NHLBI · DUKE UNIVERSITY · PI JONES, ROBERT H · 2002 to 2011
$27.3M
STICHESR01HL105853 · NHLBI · DUKE UNIVERSITY · PI AL-KHALIDI, HUSSEIN · 2011 to 2015
$10.2M
STICH Trial-Statistical and Data Coordinatiing CenterU01HL069013 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2002 to 2010
$5.0M
STICH TRIAL- Economics &Quality of Life Core LaboratoryU01HL069011 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2002 to 2008
$2.5M
STICH Trial Radionuclide Core LaboratoryU01HL069012 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BONOW, ROBERT O · 2002 to 2007
$2.0M
STICH-Trial Cardiovascular Magenetic Resonance Core LabU01HL072683 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI POHOST, GERALD MICHAEL · 2002 to 2007
$1.5M
STICH Trial-Echocardiographic Core LaboratoryU01HL069010 · NHLBI · MAYO CLINIC ROCHESTER · PI OH, JAE K · 2002 to 2007
$1.4M
Functional MR in Ischemic CardiomyopathyR01HL072430 · NHLBI · BAYLOR RESEARCH INSTITUTE · PI GRAYBURN, PAUL A · 2002 to 2007
$1.4M
DECIPHER STICHU01HL070011 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI PANZA, JULIO · 2004 to 2006
$1.2M
STICH TRIAL - NEUROHORMONAL/ CYTOKINE/ GENETIC CORE LABU01HL069009 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI FELDMAN, ARTHUR M · 2002 to 2007
$1.1M
DECIPHER STICHR01HL070011 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI PANZA, JULIO A · 2003 to 2003
backgroundWe evaluated the ability of 23 genetic variants to provide prognostic information in patients enrolled in the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
methodsPatients assigned to STICH Hypothesis 1 were randomized to medical therapy with or without coronary artery bypass grafting (CABG). Those assigned to STICH Hypothesis 2 were randomized to CABG or CABG with left ventricular reconstruction.
resultsIn patients assigned to STICH Hypothesis 2 (n = 714), no genetic variant met the prespecified Bonferroni-adjusted threshold for statistical significance (p < 0.002); however, several variants met nominal prognostic significance: variants in the β2-adrenergic receptor gene (β2-AR Gln27Glu) and in the A1-adenosine receptor gene (A1-717 T/G) were associated with an increased risk of a subject dying or being hospitalized for a cardiac problem (p = 0.027 and 0.031, respectively). These relationships remained nominally significant even after multivariable adjustment for prognostic clinical variables. However, none of the 23 genetic variants influenced all-cause mortality or the combination of death or cardiovascular hospitalization in the STICH Hypothesis 1 population (n = 532) by either univariate or multivariable analysis.
conclusionWe were unable to identify the predictive genotypes in optimally treated patients in these two ischemic heart failure populations.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials. · full record | OpenQuestion