Evidence map›Paper›PMID 25592534›Full record

ReviewNature2015

The biology of innate lymphoid cells.

David Artis, Hergen Spits

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 917 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
917citing papers in PubMed, 1 pooled it
79.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02584517 withdrawnnot on this mapstarted 2016, after this paper: background citation

Understanding the Aetiology and Pathogenesis of Giant Cell Arteritis

TypeobservationalSponsorUniversity of OxfordRan2016 to 2021Enrolled0ConditionsTemporal Arteritis
NCT02948426 phase1terminatednot on this mapstarted 2017, after this paper: background citation

Phase 1 Study of Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2017 to 2020Enrolled18ConditionsFallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal CancerArmsAutologous Monocytes + ACTIMMUNE + SYLATRON
3 · Its place in the literature

Who cites it

917 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,574 citations in OpenAlex.

  1. Pooled it
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  15. Involvement of increased arginase-1The Journal of international medical research · 2026
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857 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

David ArtisWeill Cornell Medical College, Cornell University, New York, New York 10021, USA.
Hergen SpitsAcademic Medical Center at the University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.
Amsterdam UMC Location University of Amsterdam · NLCornell University · US

Funding

Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3M
Regulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0M
Innate immunity and inflammation following helminth infectionR01AI074878 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2008 to 2019
$4.2M
Immuno-regulation of GI nematode infectionR01AI061570 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2004 to 2013
$4.1M
Regulation and function of innate lymphoid cells in the gutR01AI095466 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2011 to 2022
$3.7M
Regulation and function of innate lymphoid cells during influenza virus infectionR01AI102942 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2013 to 2017
$2.1M
Cytokine regulation of anti-helminth immunityR01AI097333 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2012 to 2016
$2.0M
NIAID NIH HHS AI061570NIAID NIH HHS AI074878NIAID NIH HHS AI095466NIAID NIH HHS AI095608NIAID NIH HHS AI097333NIAID NIH HHS AI102942NIAID NIH HHS AI106697
6 · The paper itself

Abstract

The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.

Indexed as

AnimalsHomeostasisHumansImmunity, InnateInflammationKiller Cells, NaturalLymphocytesTranscription, Genetic

Identifiers

PMID25592534
OpenAlexW2024183493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.