ArticleEpidemiology and infection2015
Environmental risk factors associated with Helicobacter pylori seroprevalence in the United States: a cross-sectional analysis of NHANES data.
Article in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori.Respiratory research · 2017Trial
- A two-sample Mendelian randomization study of the causal relationship between respiratory diseases, gastric cancer risk, and Helicobacter pylori infection.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Role of TNF-α genetic variants in coinfection with Helicobacter pylori and the Entamoeba complex: a cross-sectional study.BMC microbiology · 2026Article
- Nine-year risk stratification and prediction ofFrontiers in public health · 2025Article
- Association between triglyceride-glucose index andFrontiers in endocrinology · 2025Article
- Increasing our knowledge about the epidemiology ofInternational journal of circumpolar health · 2024Article
- The prevalence and risk factors ofMicrobiota in health and disease · 2024Article
- Article
- Association between Dietary Habits andNutrients · 2022Article
- Vietnam Association of Gastroenterology (VNAGE) consensus on the management ofFrontiers in medicine · 2022Review
- Review
- Changes in Seroprevalence ofJournal of Korean medical science · 2020Article
- Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population-based study.Helicobacter · 2018Article
- Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings.Current environmental health reports · 2016Review
- Helicobacter pylori Gastritis: Susceptible to Further Testing?Digestive diseases and sciences · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori imparts a considerable burden to public health. Infections are mainly acquired in childhood and can lead to chronic diseases, including gastric ulcers and cancer. The bacterium subsists in water, but the environment's role in transmission remains poorly understood. The nationally representative National Health and Nutrition Examination Survey (NHANES) was examined for environmental risk factors associated with H. pylori seroprevalence. Data from 1999-2000 were examined and weighted to represent the US population. Multivariable logistic regression estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) for associations with seropositivity. Self-reported general health condition was inversely associated with seropositivity. Of participants aged <20 years, seropositivity was significantly associated with having a well as the source of home tap water (aOR 1·7, 95% CI 1·1-2·6) and living in a more crowded home (aOR 2·3, 95% CI 1·5-3·7). Of adults aged ⩾20 years, seropositivity was not associated with well water or crowded living conditions, but adults in soil-related occupations had significantly higher odds of seropositivity compared to those in non-soil-related occupations (aOR 1·9, 95% CI 1·2-2·9). Exposures to both well water and occupationally related soil increased the effect size of adults' odds of seropositivity compared to non-exposed adults (aOR 2·7, 95% CI 1·3-5·6). Environmental exposures (well-water usage and occupational contact with soil) play a role in H. pylori transmission. A disproportionate burden of infection is associated with poor health and crowded living conditions, but risks vary by age and race/ethnicity. These findings could help inform interventions to reduce the burden of infections in the United States.
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