ArticleBiomacromolecules2015
Characterization of molecular transport in ultrathin hydrogel coatings for cellular immunoprotection.
Article in Biomacromolecules, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Tyrosinase Driven-Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Applications of synthetic polymers directed toward living cells.Nature synthesis · 2024Article
- Conformal encapsulation of mammalian stem cells using modified hyaluronic acid.Journal of materials chemistry. B · 2024Article
- Exploring Novel Sensor Design Ideas through Concentration-Induced Conformational Changes in PEG Single Chains.Sensors (Basel, Switzerland) · 2024Article
- Surface-Immobilized Photoinitiators for Light Induced Polymerization and Coupling Reactions.Polymers · 2022Review
- Increased Retention of Cardiac Cells to a Glass Substrate through Streptavidin-Biotin Affinity.ACS omega · 2021Article
- Cell Death Persists in Rapid Extrusion of Lysis-Resistant Coated Cardiac Myoblasts.Bioprinting (Amsterdam, Netherlands) · 2020Article
- Cyto-friendly polymerization at cell surfaces modulates cell fate by clustering cell-surface receptors.Chemical science · 2020Article
- Gelatin Based Polymer Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after Myocardial Infarction.Stem cell reviews and reports · 2019Article
- Coatings on mammalian cells: interfacing cells with their environment.Journal of biological engineering · 2019Review
- A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors.Nature communications · 2018Article
- Comparison of eosin and fluorescein conjugates for the photoinitiation of cell-compatible polymer coatings.PloS one · 2018Article
- Hydrogel Patches on Live Cells through Surface-Mediated Polymerization.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization.Nature chemistry · 2017Article
- The Role of Surface Receptor Density in Surface-Initiated Polymerizations for Cancer Cell Isolation.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Protective Polymer Coatings for High-Throughput, High-Purity Cellular Isolation.ACS applied materials & interfaces · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
PEG hydrogels are routinely used in immunoprotection applications to hide foreign cells from a host immune system. Size-dependent transport is typically exploited in these systems to prevent access by macromolecular elements of the immune system while allowing the transport of low molecular weight nutrients. This work studies a nanoscale hydrogel coating for improved transport of beneficial low molecular weight materials across thicker hydrogel coatings while completely blocking transport of undesired larger molecular weight materials. Coatings composed of PEG diacrylate of molecular weight 575 and 3500 Da were studied by tracking the transport of fluorescently labeled dextrans across the coatings. The molecular weight of dextran at which the transport is blocked by these coatings are consistent with cutoff values in analogous bulk PEG materials. Additionally, the diffusion constants of 4 kDa dextrans across PEG 575 coatings (9.5 × 10(-10)-2.0 × 10(-9) cm(2)/s) was lower than across PEG 3500 coatings (5.9-9.8 × 10(-9) cm(2)/s), and these trends and magnitudes agree with bulk scale models. Overall, these nanoscale thin PEG diacrylate films offer the same size selective transport behavior of bulk PEG diacrylate materials, while the lower thickness translates directly to increased flux of beneficial low molecular weight materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.