Evidence map›Paper›PMID 25592090›Full record

ReviewClinical therapeutics2015

Cervical cancer survivorship: long-term quality of life and social support.

Krista S Pfaendler, Lari Wenzel, Mindy B Mechanic, Kristine R Penner

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 78 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04165460 naenrolling by invitationnot on this mapstarted 2020, after this paper: background citation

Effect of Two Cognitive-Behavioral Interventions on Psychosocial Factors and Quality of Life of Cervical Cancer Patients With Locally-advanced and Advanced Disease

TypeinterventionalSponsorNational Institute of CancerologíaRan2020 to 2025Enrolled92ConditionsCervical Cancer, Psychological Distress, Coping SkillsArmsPsychoeducation, Relaxation, Cognitive Restructuring, Solving Problems
NCT04184154 completednot on this mapstarted 2017, after this paper: background citation

Vaginal Dilatators and Moisturizers Use and Sexual Quality of Life of Patients With Gynecologic Cancer Treated With Brachytherapy.

TypeobservationalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2017 to 2017Enrolled167ConditionsPelvic Cancer, Cervical CancerArmsQuestionnaires
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. A systematic review of the impact of contemporary treatment modalities for cervical cancer on women's self-reported health-related quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  5. Calidad de Vida: a systematic review of quality of life in Latino cancer survivors in the USA.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020
    Pooled it
  6. Pooled it
  7. Trial
  8. A nurse-led theory-based psycho-educational intervention programme for women with gynaecological cancer: a multicentre randomised controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  9. Trial
  10. Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Trial
  11. Trial
  12. Trial
  13. Factors Affecting Quality of Life of Thai Cervical Cancer Patients.The journal of obstetrics and gynaecology research · 2026
    Article
  14. Article
  15. Post-traumatic growth and cancer survivorship: experiences of living with treatment-related impairment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  16. Article
  17. Morbidity of radical surgery and postoperative radiotherapy in cervical cancer.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Review
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Krista S PfaendlerDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California at Irvine Medical Center, Orange, California.
Lari WenzelProgram in Public Health, University of California, Irvine, Irvine, California; Department of Medicine and Program in Public Health, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California.
Mindy B MechanicDepartment of Psychology, California State University, Fullerton, Fullerton, California.
Kristine R PennerDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California at Irvine Medical Center, Orange, California. Electronic address: kpennerk@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32CA060396 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRISTOW, ROBERT EDWARD · 1994 to 2020
$4.6M
Stress, Immunity & Cervical Cancer: Biobehavioral Outcomes of a Randomized TrialR01CA118136 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WENZEL, LARI · 2007 to 2011
$2.3M
CSUF and UCI-CFCCC Partnership for Cancer Health Disparities Research (1 of 2)P20CA174292 · NCI · CALIFORNIA STATE UNIVERSITY FULLERTON · PI TANJASIRI, SORA P · 2012 to 2015
$739k
CSUF and UCI-CFCCC Partnership for Cancer Health Disparities Research (2 of 2)P20CA174188 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUBBELL, FLOYD ALLAN · 2012 to 2015
$583k
NCI NIH HHS P20 CA174188NCI NIH HHS P20 CA174292NCI NIH HHS P20CA174292-01NCI NIH HHS P30 CA062203NCI NIH HHS P30CA-62203-14NCI NIH HHS R01 CA118136NCI NIH HHS R01CA118136-05NCI NIH HHS T32 CA060396
6 · The paper itself

Abstract

purposeSurgery, radiotherapy, and chemotherapy are the mainstays of cervical cancer treatment. Many patients receive multiple treatment modalities, each with its own long-term effects. Given the high 5-year survival rate for cervical cancer patients, evaluation and improvement of long-term quality of life are essential.

methodsPertinent articles were identified through searches of PubMed for literature published from 1993 to 2014. We summarize quality of life data from long-term follow-up studies of cervical cancer patients. We additionally summarize small group interviews of Hispanic and non-Hispanic cervical cancer survivors regarding social support and coping.

findingsData are varied in terms of the long-term impact of treatment on quality of life, but consistent in suggesting that patients who receive radiotherapy as part of their treatment have the highest risk of increased long-term dysfunction of bladder and bowel, as well as sexual dysfunction and psychosocial consequences. Rigorous investigations regarding long-term consequences of treatment modalities are lacking. IMPLICATIONS: Continued work to improve treatment outcomes and survival should also include a focus on reducing adverse long-term side effects. Providing supportive care during treatment and evaluating the effects of supportive care can reduce the prevalence and magnitude of long-term sequelae of cervical cancer, which will in turn improve quality of life and quality of care.

Indexed as

Quality of LifeSocial SupportFemaleHumansMiddle AgedSurvival RateSurvivorsUterine Cervical Neoplasmscervical cancerlong-term effectsquality of lifesurvivorship

Identifiers

PMID25592090
PMCPMC4404405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.