Evidence map›Paper›PMID 25591985›Full record

ReviewTrends in endocrinology and metabolism: TEM2015

Power(2): the power of yeast genetics applied to the powerhouse of the cell.

Jared Rutter, Adam L Hughes

Open access · greenAbstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Identification of RNA-Binding Protein Targets with HyperTRIBE inInternational journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Isolation and Quality Control of Yeast Mitochondria.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  10. The [PSIMolecular biology of the cell · 2022
    Article
  11. Molecular and cellular biology · 2021
    Article
  12. Article
  13. Article
  14. Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jared RutterDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: rutter@biochem.utah.edu.
Adam L HughesDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: hughes@biochem.utah.edu.
University of Utah · US

Funding

Succinate Dehydrogenase: Biogenesis and Role in DiseaseR01GM110755 · NIGMS · UNIVERSITY OF UTAH · PI WINGE, DENNIS R. · 2014 to 2021
$2.3M
Establishing the role of the atypical kinase ADCK3 in mitochondrial metabolismR01GM112057 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PAGLIARINI, DAVID J · 2014 to 2017
$1.3M
Functions of the Mitochondrial Proteome: An Integrated Multi-Species ApproachR01GM094232 · NIGMS · UNIVERSITY OF UTAH · PI RUTTER, JARED P, THUMMEL, CARL S. · 2012 to 2015
$1.2M
Role of Mitophagy in Mitochondrial Protein Quality ControlR00AG043095 · NIA · UNIVERSITY OF UTAH · PI HUGHES, ADAM · 2014 to 2016
$740k
Role of Mitophagy in Mitochondrial Protein Quality ControlK99AG043095 · NIA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HUGHES, ADAM · 2013 to 2013
$90k
NIA NIH HHS AG043095NIA NIH HHS K99 AG043095NIA NIH HHS R00 AG043095NIGMS NIH HHS GM094232NIGMS NIH HHS GM110755NIGMS NIH HHS GM112057NIGMS NIH HHS R01 GM094232NIGMS NIH HHS R01 GM110755NIGMS NIH HHS R01 GM112057
6 · The paper itself

Abstract

The budding yeast Saccharomyces cerevisiae has served as a remarkable model organism for numerous seminal discoveries in biology. This paradigm extends to the mitochondria, a central hub for cellular metabolism, where studies in yeast have helped to reinvigorate the field and launch an exciting new era in mitochondrial biology. Here we discuss a few recent examples in which yeast research has laid a foundation for our understanding of evolutionarily conserved mitochondrial processes and functions, from key factors and pathways involved in the assembly of oxidative phosphorylation (OXPHOS) complexes to metabolite transport, lipid metabolism, and interorganelle communication. We also highlight new areas of yeast mitochondrial biology that are likely to aid in our understanding of the mitochondrial etiology of disease in the future.

Indexed as

AnimalsBiological TransportCell Physiological PhenomenaGenetic TechniquesHumansMetabolic Networks and PathwaysMitochondriaOxidative PhosphorylationSaccharomyces cerevisiaeinterorganelle communicationlipid metabolismmitochondriaoxidative phosphorylationtransportersyeast

Identifiers

PMID25591985
PMCPMC4315768
OpenAlexW1994596631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.