Observational studyNephron. Clinical practice2014
Association of de novo dipstick albuminuria with severe acute kidney injury in critically ill septic patients.
Observational study in Nephron. Clinical practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Risk factors for predicting acute kidney injury in children with septic shock: a retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Beyond Liver Function:Sultan Qaboos University medical journal · 2025Article
- Albuminuria, Forgotten No More: Underlining the Emerging Role in CardioRenal Crosstalk.Journal of clinical medicine · 2024Review
- Acute kidney injury in hospitalized children with proteinuria: A multicenter retrospective analysis.PloS one · 2024Article
- Critically ill patients with acute kidney injury: clinical determinants and post-mortem histology.Clinical kidney journal · 2023Article
- Preoperative dipstick albuminuria is associated with acute kidney injury in high-risk patients following non-cardiac surgery: a single-center prospective cohort study.Journal of anesthesia · 2022Article
- Acute Kidney Injury in Critically-Ill COVID-19 Patients.Journal of clinical medicine · 2022Article
- Sepsis-Associated Acute Kidney Injury.Critical care clinics · 2021Review
- Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model.Intensive care medicine experimental · 2020Article
- Identifying KDIGO Trajectory Phenotypes Associated with Increased Inpatient Mortality.Proceedings. IEEE International Conference on Healthcare Informatics · 2019Article
- Urine Klotho Is Lower in Critically Ill Patients With Versus Without Acute Kidney Injury and Associates With Major Adverse Kidney Events.Critical care explorations · 2019Article
- Impact of Recent Clinical Trials on Nephrology Practice: Are We in a Stagnant Era?Kidney diseases (Basel, Switzerland) · 2019Review
- Sepsis associated acute kidney injury.BMJ (Clinical research ed.) · 2019Review
- Risk Prediction Models for Acute Kidney Injury in Critically Ill Patients: Opus in Progressu.Nephron · 2018Review
- Renal recovery after acute kidney injury.Intensive care medicine · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundAcute kidney injury (AKI) occurs frequently in septic patients. Albuminuria may play a role as an early marker of septic AKI. The potential association between de novo dipstick albuminuria (DA) and septic AKI has not been examined.
methodsWe conducted a single-center observational cohort study of 423 critically ill septic patients without chronic kidney disease (CKD) or prior positive DA within 3 months before admission. The association between de novo DA within the first 24 h of presentation and AKI at 72 h was examined.
resultsAKI was identified in 268/423 (63%) patients and 20/423 (4.7%) required dialysis. De novo DA was associated with AKI (univariate OR 1.91; 95% CI 1.27-2.86, p = 0.002). The association persisted in a multivariate logistic regression model adjusted for demographics, baseline kidney function, comorbidities, critical illness parameters, and exposure to nephrotoxins (adjusted OR 1.87; 95% CI 1.21-2.89, p = 0.005). The association between de novo DA and AKI was stronger for severe AKI, i.e. Acute Kidney Injury Network (AKIN) stage 3 (adjusted OR 2.99; 95% CI 1.52-5.85, p = 0.001) and AKIN stage 2 (adjusted OR 1.79; 95% CI 1.002-3.21, p = 0.049) but not AKIN stage 1 (adjusted OR 1.41; 95% CI 0.87-2.29, p = 0.16).
conclusionsDe novo DA within the first 24 h of admission was independently associated with severe AKI in critically ill septic patients. Future studies are required to fully elucidate the utility of DA testing in the early detection and stratification of AKI.
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