Observational studyEuropean radiology2015
Opportunistic screening for osteoporosis on routine computed tomography? An external validation study.
Observational study in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- Diagnostic performance of lumbar computed tomography Hounsfield unit thresholds for osteoporosis and osteopenia: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Trial
- Computed tomography-measured trabecular attenuation at first lumbar vertebra as a surrogate marker of bone mineral density and osteoporosis in patients undergoing hemodialysis.Renal failure · 2026Article
- Repeatability of AI-quantified incidental findings on lung cancer screening CT scans in the NELSON trial.European radiology · 2026Article
- Article
- A novel CT soft tissue window-based visual scoring system for rapid assessment of bone density.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Article
- Progress in machine learning-assisted medical imaging for osteoarthritis and osteoporosis diagnosis: a narrative review.Quantitative imaging in medicine and surgery · 2026Review
- Lumbar MRI-Based Deep Learning for Osteoporosis Prediction.Diagnostics (Basel, Switzerland) · 2026Article
- Opportunistic computed tomography assessment of bone, muscle, and adipose tissue: evidence, limitations, and clinical translation.Frontiers in medicine · 2026Review
- Hounsfield unit values in patients with diffuse idiopathic skeletal hyperostosis and thoracolumbar injuries - a single-center retrospective study.BMC musculoskeletal disorders · 2025Article
- Opportunistic screening for osteoporosis: validation study for L1 bone density measurements using contrast-enhanced chest and abdominal CTs.Skeletal radiology · 2025Article
- Article
- Opportunistic assessment of bone mineral density in cystic fibrosis patients using ultra-low dose thoracic CT.Archives of osteoporosis · 2025Article
- Osteoporosis in Adult Patients Undergoing Spinal Reconstructive Surgery: Associated Complications and Management.Global spine journal · 2025Article
- Age-dependent changes in CT vertebral attenuation values in opportunistic screening for osteoporosis: a nationwide multi-center study.European radiology · 2025Article
- Artificial intelligence assisted automatic screening of opportunistic osteoporosis in computed tomography images from different scanners.European radiology · 2025Article
- Comparison of thoracic vertebrae and L1 CT attenuation in predicting osteoporosis using opportunistic chest CT.Therapeutic advances in musculoskeletal disease · 2025Article
- Opportunistic Screening for Osteoporosis by CT as Compared with DXA.Diagnostics (Basel, Switzerland) · 2024Article
- Forearm bone mineral density as a predictor of adjacent vertebral refracture after percutaneous kyphoplasty in patients with osteoporotic vertebral compression fracture: a retrospective analysis.Journal of orthopaedic surgery and research · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOpportunistic screening for osteoporosis using computed tomography (CT) examinations that happen to visualise the spine can be used to identify patients with osteoporosis. We sought to verify the diagnostic performance of vertebral Hounsfield unit (HU) measurements on routine CT examinations for diagnosing osteoporosis in a separate, external population.
methodsConsecutive patients who underwent a CT examination of the chest or abdomen and had also received a dual-energy X-ray absorptiometry (DXA) test were retrospectively included. CTs were evaluated for vertebral fractures and vertebral attenuation (density) values were measured. Diagnostic performance measures and the area under the receiver operator characteristics curve (AUC) for diagnosing osteoporosis were calculated.
resultsThree hundred and two patients with a mean age of 57.9 years were included, of which 82 (27%) had osteoporosis according to DXA and 65 (22%) had vertebral fractures. The diagnostic performance for vertebral HU measurements was modest, with a maximal AUC of 0.74 (0.68 - 0.80). At that optimal threshold the sensitivity was 62% (51 - 72%) and the specificity was 79% (74 - 84%).
conclusionsWe confirmed that simple trabecular vertebral density measurements on routine CT contain diagnostic information related to bone mineral density as measured by DXA, albeit with substantially lower diagnostic accuracy than previously reported. KEY POINTS: • We externally validated the value of vertebral trabecular bone attenuation for osteoporosis • These diagnostic performance measures were, however, substantially lower than previously reported • This information might be useful when considering the implementation of opportunistic osteoporosis screening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.