ArticleRheumatology international2015
Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets.
Article in Rheumatology international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 20 citations in OpenAlex.
- Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population.BMC urology · 2023Article
- Genetic Variation in theFrontiers in genetics · 2022Article
- Trends in the Contribution of Genetic Susceptibility Loci to Hyperuricemia and Gout and Associated Novel Mechanisms.Frontiers in cell and developmental biology · 2022Review
- Article
- Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer.Molecular genetics & genomic medicine · 2020Article
- Association of SNPs in the OBFC1 gene and laryngeal carcinoma in Chinese Han male population.International journal of clinical oncology · 2019Article
- Genetic variants in the ITPR2 gene are associated with Kashin-Beck Disease in Tibetan.Molecular genetics & genomic medicine · 2019Article
- ZNF518B gene up-regulation promotes dissemination of tumour cells and is governed by epigenetic mechanisms in colorectal cancer.Scientific reports · 2019Article
- Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population.Oncotarget · 2018Article
- Association between IL-1 gene polymorphisms and tuberculosis susceptibility in the Chinese Tibetan population.International journal of clinical and experimental pathology · 2018Article
- The impact of the AHSG genetic polymorphism on the risk of ischemic stroke: a case-control study.International journal of clinical and experimental pathology · 2018Article
- Angiotensin II receptor 1 gene variants are associated with high-altitude pulmonary edema risk.Oncotarget · 2016Article
- WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients.Rheumatology international · 2016Article
- Genetic Susceptibility to Vitiligo: GWAS Approaches for Identifying Vitiligo Susceptibility Genes and Loci.Frontiers in genetics · 2016Review
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A genome-wide association study of gout in European populations identified 12 genetic variants strongly associated with risk of gout, but it is unknown whether these variants are also associated with gout risk in Chinese populations. A total of 145 patients with gout and 310 healthy control patients were recruited for a case-control association study. Twelve SNPs of CLNK and ZNF518B gene were genotyped, and association analysis was performed. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the association. Overall, we found four risk alleles for gout in patients: the allele "G" of rs2041215 and rs1686947 in the CLNK gene by dominant model (OR 1.66; 95 % CI 1.04-2.63; p = 0.031) (OR 2.19; 95 % CI 1.38-3.46; p = 0.001) and additive model (OR 1.39; 95 % CI 1.00-1.93; p = 0.049) (OR 1.67; 95 % CI 1.19-2.32; p = 0.003), respectively, and the allele "A" of rs10938799 and rs10016022 in ZNF518B gene by recessive model (OR 4.66; 95 % CI 1.44-15.09; p = 0.008) (OR 4.54; 95 % CI 1.23-16.76; p = 0.020). Further haplotype analysis showed that the TCATTCTGA haplotype of CLNK was more frequent among patients with gout (adjusted OR 0.48; 95 % CI 0.24-0.95; p = 0.036). Additionally, polymorphisms of rs2041215, rs10938799, and rs17467273 were also correlated with clinical pathological parameters. This study provides evidence for gout susceptibility genes, CLNK and ZNF518B, in a Chinese population, which may have potential as diagnostic and prognostic marker for gout patients.
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