ReviewAnnals of clinical microbiology and antimicrobials2015
Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity.
Review in Annals of clinical microbiology and antimicrobials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Trends and advances inFrontiers in microbiology · 2024Pooled it
- Multi-omics analysis of human patient samples identifies key immune factors inMicrobiology spectrum · 2026Article
- Evaluating the diagnostic accuracy of clinical judgement and rapid tests for leptospirosis in the Philippines: implications for public health management.Infectious diseases of poverty · 2026Article
- Predictors of severe leptospirosis: a review.European journal of medical research · 2025Review
- Leptospirosis.Nature reviews. Disease primers · 2025Review
- Beyond serology: saccharide profiling enables identification of antigenically similarFrontiers in molecular biosciences · 2025Article
- Advancing serologic diagnosis: assessing the efficacy of rErpY-like protein in human leptospirosis detection.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Review of leptospirosis in dogs from Mexico: Epidemiology, diagnosis, prevention, and treatment.Veterinary world · 2024Review
- Modelling the Unidentified Abortion Burden from Four Infectious Pathogenic Microorganisms (Animals : an open access journal from MDPI · 2023Article
- Evaluating immunochromatographic test kits for diagnosis of acute human leptospirosis: A systematic review.Heliyon · 2022Review
- Diagnosis of Human Leptospirosis: Comparison of Microscopic Agglutination Test with Recombinant LigA/B Antigen-Based In-House IgM Dot ELISA Dipstick Test and Latex Agglutination Test Using Bayesian Latent Class Model and MAT as Gold Standard.Diagnostics (Basel, Switzerland) · 2022Article
- Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting.PLoS neglected tropical diseases · 2022Article
- Leptospirosis: clinical aspects.Clinical medicine (London, England) · 2022Review
- Estimating the burden of leptospirosis: global lessons from Sri Lanka.BMJ global health · 2021Article
- Leptospirosis with pulmonary haemorrhage and multiple organ failure: a case report and literature review.The Journal of international medical research · 2021Review
- Leptospirosis diagnosis among patients suspected of dengue fever in Brazil.The journal of venomous animals and toxins including tropical diseases · 2021Article
- Assessment of Serum Macrophage Migration Inhibitory Factor (MIF) as an Early Diagnostic Marker of Leptospirosis.Frontiers in cellular and infection microbiology · 2021Article
- Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- Leptospiral 3-hydroxyacyl-CoA dehydrogenase as an early urinary biomarker of leptospirosis.Heliyon · 2018Article
- Clinical and Epidemiological Status of Leptospirosis in a Tropical Caribbean Area of Colombia.BioMed research international · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis is a zoonotic spirochaetal illness that is endemic in many tropical countries. The research base on leptospirosis is not as strong as other tropical infections such as malaria. However, it is a lethal infection that can attack many vital organs in its severe form, leading to multi-organ dysfunction syndrome and death. There are many gaps in knowledge regarding the pathophysiology of leptospirosis and the role of host immunity in causing symptoms. This hinders essential steps in combating disease, such as developing a potential vaccine. Another major problem with leptospirosis is the lack of an easy to perform, accurate diagnostic tests. Many clinicians in resource limited settings resort to clinical judgment in diagnosing leptospirosis. This is unfortunate, as many other diseases such as dengue, hanta virus, rickettsial infections, and even severe bacterial sepsis, can mimic leptospirosis. Another interesting problem is the prediction of disease severity at the onset of the illness. The majority of patients recover from leptospirosis with only a mild febrile illness, while a few others have severe illness with multi-organ failure. Clinical features are poor predictors of potential severity of infection, and therefore the search is on for potential biomarkers that can serve as early warnings for severe disease. This review concentrates on these three important aspects of this neglected tropical disease: diagnostics, developing a vaccine, and potential biomarkers to predict disease severity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.