ArticlePublic health nutrition2015
Genetic and environmental factors associated with vitamin B12 status in Amazonian children.
Article in Public health nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Vitamin BFrontiers in nutrition · 2025Article
- Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents.Scientific reports · 2021Article
- Serum folate and vitamin B12 status in young Brazilian children.Public health nutrition · 2019Article
- An update on vitamin B12-related gene polymorphisms and B12 status.Genes & nutrition · 2018Review
- Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the prevalence of vitamin B12 deficiency and factors associated with vitamin B12 status in Amazonian children.
designGenetic risk score (GRS), socio-economic and nutritional status, and morbidity data were the independent variables used in multiple linear regression models to evaluate factors associated with vitamin B12 status in a population-based cross-sectional study. GRS was created by summing a number of known risk alleles for low serum vitamin B12.
settingAcrelândia, western Brazilian Amazon. SUBJECTS: Children (n 988) aged <10 years.
resultsOverall prevalence of vitamin B12 deficiency (<150 pmol/l) was 4·2 (95 % CI 3·0, 5·6) % and was highest in children aged <24 months: 13·6 (95 % CI % 8·8, 19·7) %. For children <24 months, wealth index (β=0·017, P=0·030) and animal protein intake (β=0·219, P=0·003) were positively associated with vitamin B12 status. GRS (β=-0·114, P<0·001) and serum homocysteine (β=-0·049, P<0·001) were negatively associated. Among children aged ≥24 months, vitamin B12 status was positively associated with wealth index (β=0·012, P<0·001), height-for-age Z-score (β=0·024, P=0·033) and serum vitamin A (β=0·089, P<0·001). Age≥60 months (β=-0·118, P<0·001), GRS (β=-0·048, P<0·001), maternal schooling <5 years (β=-0·083, P<0·001), low intake of animal-derived foods (β=-0·050, P=0·030), serum homocysteine (β=-0·053, P<0·001), serum folate ≥23·6 nmol/l (β=-0·055, P=0·012) and geohelminth infection (β=-0·141, P=0·017) were negatively associated with vitamin B12 status.
conclusionsGRS, poverty, low intake of animal-derived foods, geohelminth infection, vitamin A and folate status were important factors associated with vitamin B12 status of children in our study.
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