ArticleProceedings of the National Academy of Sciences of the United States of America2015
Seminal CD38 is a pivotal regulator for fetomaternal tolerance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Seminal fluid effects on female reproductive function in laboratory, livestock, and domestic species.The Journal of reproduction and development · 2026Review
- Environmental influences on seminal plasma: Molecular and functional insights.The Journal of reproduction and development · 2026Review
- Immunological Causes of Infertility: Diagnostic Perspectives.Biomolecules · 2025Review
- Adverse neonatal outcomes are associated with a sex-specific placental inflammatory profile†.Biology of reproduction · 2025Article
- Targets for CAR Therapy in Multiple Myeloma.International journal of molecular sciences · 2025Review
- Seminal plasma metabolomics and sperm lipidomics profiles of bull semen with different total progressive motile sperm count.Journal of animal science · 2025Article
- Assessing Seminal Fluid Interaction with Female Reproductive Tract Tissues: In Vivo and In Vitro Models for Mouse.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Seminal plasma uterine priming alters uterine transcriptomics and negatively impacts embryo growth and uterine artery resistance but not offspring liver transcriptomics in beef cattle.Journal of animal science · 2024Article
- The endometrial transcriptome transition preceding receptivity to embryo implantation in mice.BMC genomics · 2023Article
- Memory regulatory T cells in pregnancy.Frontiers in immunology · 2023Review
- Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity.Clinical and experimental immunology · 2022Article
- Pregnancy and Tumour: The Parallels and Differences in Regulatory T Cells.Frontiers in immunology · 2022Review
- Toll-like receptor-4 null mutation causes fetal loss and fetal growth restriction associated with impaired maternal immune tolerance in mice.Scientific reports · 2021Article
- Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice.Communications biology · 2021Article
- The role of CD38 in HIV infection.AIDS research and therapy · 2021Review
- Immunoendocrine Markers of Stress in Seminal Plasma at IVF/ICSI Failure: a Preliminary Study.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Perspective: Re-defining "Pheromone" in a Mammalian Context to Encompass Seminal Fluid.Frontiers in veterinary science · 2021Review
- Review
- Dynamic Changes in the Phenotype of Dendritic Cells in the Uterus and Uterine Draining Lymph Nodes After Coitus.Frontiers in immunology · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A successful pregnancy depends on a complex process that establishes fetomaternal tolerance. Seminal plasma is known to induce maternal immune tolerance to paternal alloantigens, but the seminal factors that regulate maternal immunity have yet to be characterized. Here, we show that a soluble form of CD38 (sCD38) released from seminal vesicles to the seminal plasma plays a crucial role in inducing tolerogenic dendritic cells and CD4(+) forkhead box P3(+) (Foxp3(+)) regulatory T cells (Tregs), thereby enhancing maternal immune tolerance and protecting the semiallogeneic fetus from resorption. The abortion rate in BALB/c females mated with C57BL/6 Cd38(-/-) males was high compared with that in females mated with Cd38(+/+) males, and this was associated with a reduced proportion of Tregs within the CD4(+) T-cell pool. Direct intravaginal injection of sCD38 to CBA/J pregnant mice at preimplantation increased Tregs and pregnancy rates in mice under abortive sonic stress from 48 h after mating until euthanasia. Thus, sCD38 released from seminal vesicles to the seminal plasma acts as an immunoregulatory factor to protect semiallogeneic fetuses from maternal immune responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.