ArticleBehavioural brain research2015
Sex-specific impairment and recovery of spatial learning following the end of chronic unpredictable restraint stress: potential relevance of limbic GAD.
Article in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Chronic Stress Disrupts Immune and Endocrine Axis, Inducing Persistent Behavioral Impairments in Male Rats: In Silico and In Vivo Insights.Neurochemical research · 2025Article
- Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well.Biological psychiatry global open science · 2025Article
- Inhibition of prefrontal glutamatergic neuron activity during the recovery period following chronic stress disrupts fear memory in male rats: potential role of the infralimbic cortex.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats.Hormones and behavior · 2024Article
- Sex differences in cognition following variations in endocrine status.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Review
- Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex.Neurobiology of stress · 2021Article
- Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Effect of Cold Stress on Neurobehavioral and Physiological Parameters in Rats.Frontiers in physiology · 2021Article
- The Molecular Basis of Depression: Implications of Sex-Related Differences in Epigenetic Regulation.Frontiers in molecular neuroscience · 2021Article
- Chronic stress has lasting effects on improved cued discrimination early in extinction.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Chronic unpredictable intermittent restraint stress disrupts spatial memory in male, but not female rats.Behavioural brain research · 2020Article
- Repeated Exposure to Multiple Concurrent Stresses Induce Circuit Specific Loss of Inputs to the Posterior Parietal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Prior stress followed by a novel stress challenge results in sex-specific deficits in behavioral flexibility and changes in gene expression in rat medial prefrontal cortex.Hormones and behavior · 2020Article
- α7 nicotinic receptor full agonist reverse basolateral amygdala hyperactivity and attenuation of dopaminergic neuron activity in rats exposed to chronic mild stress.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2019Article
- Transcriptomic Analysis Reveals Sex-Dependent Expression Patterns in the Basolateral Amygdala of Dominant and Subordinate Animals After Acute Social Conflict.Molecular neurobiology · 2019Article
- Sex differences in stress regulation of arousal and cognition.Physiology & behavior · 2018Review
- Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases.Frontiers in neuroscience · 2018Review
- Effects of repeated restraint stress and WiFi signal exposure on behavior and oxidative stress in rats.Metabolic brain disease · 2017Article
- Synaptic Plasticity, Metaplasticity and Depression.Current neuropharmacology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic restraint stress alters hippocampal-dependent spatial learning and memory in a sex-dependent manner, impairing spatial performance in male rats and leaving intact or facilitating performance in female rats. Moreover, these stress-induced spatial memory deficits improve following post-stress recovery in males. The current study examined whether restraint administered in an unpredictable manner would eliminate these sex differences and impact a post-stress period on spatial ability and limbic glutamic acid decarboxylase (GAD65) expression. Male (n=30) and female (n=30) adult Sprague-Dawley rats were assigned to non-stressed control (Con), chronic stress (Str-Imm), or chronic stress given a post-stress recovery period (Str-Rec). Stressed rats were unpredictably restrained for 21 days using daily non-repeated combinations of physical context, duration, and time of day. Then, all rats were tested on the radial arm water maze (RAWM) for 2 days and given one retention trial on the third day, with brains removed 30min later to assess GAD65 mRNA. In Str-Imm males, deficits occurred on day 1 of RAWM acquisition, an impairment that was not evident in the Str-Rec group. In contrast, females did not show significant outcomes following chronic stress or post-stress recovery. In males, amygdalar GAD65 expression negatively correlated with RAWM performance on day 1. In females, hippocampal CA1 GAD65 positively correlated with RAWM performance on day 1. These results demonstrate that GABAergic function may contribute to the sex differences observed following chronic stress. Furthermore, unpredictable restraint and a recovery period failed to eliminate the sex differences on spatial learning and memory.
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